母体丁丙诺啡治疗对胎儿和婴儿神经行为的影响-猫眼课题宝

母体丁丙诺啡治疗对胎儿和婴儿神经行为的影响

批准号：

8858597

负责人：

LAUREN M JANSSON

金额：

$49.63万

依托单位：

JOHNS HOPKINS UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-08-01 至 2018-05-31

来源：

https://reporter.nih.gov/project-details/8858597

关键词：

Affect Age-Months Birth Buprenorphine Clinical Clinical Research Complex Cross-Sectional Studies Data Data Collection Dependency Development Digestive Signs and Symptoms Dose Exhibits Fetus Functional disorder Gestational Age Goals Guidelines Incidence Infant Infant autonomic nervous system Knowledge Maintenance Mediating Methadone Mothers Neonatal Neonatal Abstinence Syndrome Nervous system structure Neurobiology Newborn Infant Opiates Opioid Outcome Patients Perinatal Pharmaceutical Preparations Physiological Population Pregnancy Pregnant Women Problem behavior Provider Recruitment Activity Research Research Personnel Research Project Grants Respiratory System Safety Schedule Second Pregnancy Trimester Severities Study Subject Symptoms Techniques Third Pregnancy Trimester Time Withdrawal Woman Work cohort experience fetal improved in utero interest neonate neurobehavior neurobehavioral pregnant research facility

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英文摘要

DESCRIPTION (provided by applicant): The population of opioid dependent pregnant women and their fetuses and infants are a highly vulnerable and complex group that are currently poorly understood. Infants display a range of physiologic and behavioral problems that are widely variable, have unknown pathophysiology, and are characterized by significant deficits in neuroregulatory functioning. Research by this team has shown that methadone negatively affects fetal neurobehaviors in late gestation, and that severity of newborn neuroregulatory dysfunction is related to maternal and infant autonomic nervous system activity. New research has shown the optimality of buprenorphine maintenance during pregnancy as compared to methadone, principally due to improved neonatal outcomes, which is likely to result in increased numbers of providers and patients seeking this medication for treatment of opioid dependency during pregnancy. However, little information regarding the effects of buprenorphine on the developing fetus and infant exists. Pilot data from this group of investigators has suggested that buprenorphine, as compared to methadone-exposed fetuses, exhibit more optimal fetal functioning in the second and third trimesters of gestation. With this proposed research project, we intend to track the longitudinal neurobehavioral development of the buprenorphine-exposed fetus across gestation through 1 month of age in an effort to determine the safety of this medication for use during gestation, the relationship between maternal physiologic changes due to buprenorphine administration and newborn functioning, and to determine potential fetal neurobehavioral markers that may predict NAS expression and infant neurobehavioral outcome. Comparisons to results from a similar project in methadone-exposed pregnancies will be made. This proposal seeks to advance the way we inform the treatment of the opioid dependent woman during pregnancy and her infant after birth.

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