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IGF::OT::IGF PHARMACOLGY AND TOXICOLOGY STUDIES OF AMAKACIN AND SUTEZOLID, AND SUPPORT THE DEVELOPMENT OF BIOMARKER AND MITOCHONDRIAL TOXICITY ASSAYS

IGF::OT::IGF PHARMACOLGY AND TOXICOLOGY STUDIES OF AMAKACIN AND SUTEZOLID, AND SUPPORT THE DEVELOPMENT OF BIOMARKER AND MITOCHONDRIAL TOXICITY ASSAYS
IGF::OT::IGF Amakacin 和 Sutezolid 的药理学和毒理学研究，并支持生物标志物和线粒体毒性测定的开发
批准号：
8938944
负责人：
Jon Carl Mirsalis
金额：
$189.89万
依托单位：
SRI INTERNATIONAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-09-19 至 2015-09-18
来源：
https://reporter.nih.gov/project-details/8938944
关键词：
Acquired Immunodeficiency SyndromeAnimalsBiologicalBiological AssayBiological AvailabilityBiological MarkersCanis familiarisCardiovascular systemClinical TrialsContractsDevelopmentDevelopment PlansDoseDrug FormulationsDrug InteractionsDrug KineticsExcretory functionFecesG protein coupled receptor kinaseGenitourinary systemHIVHIV InfectionsImmunologicsIn VitroLiquid substanceMetabolismMitochondriaModelingMusNational Institute of Allergy and Infectious DiseaseNeuraxisNo-Observed-Adverse-Effect LevelPharmacodynamicsPharmacologic SubstancePharmacologyPlasmaPlasma ProteinsProtein BindingProteomicsRattusReference StandardsResearch PersonnelSafetySamplingServicesSexual TransmissionSystemTestingTherapeutic AgentsTherapeutic EquivalencyTissuesToxic effectToxicogenomicsToxicologyUnited States Dept. of Health and Human ServicesUnited States National Institutes of HealthUrineabsorptioncarcinogenicitydrug developmentgastrointestinalgenotoxicityimmunotoxicityin vivometabolomicsmicrobicidenonhuman primatepreventreproductiverespiratory

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英文摘要
The Division of Acquired Immunodeficiency Syndromes (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), maintains a portfolio of contracts to support the development of (1) therapies for HIV infection and its complications and coinfections, and (2) microbicides for preventing the sexual transmission of HIV. Services provided under this contracts assist investigators in academic settings and small pharmaceutical firms in filling specific gaps in their drug development plan as they advance their product towards clinical investigation.
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Task Order 3: Interventional Agent Development Services Program
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  • 依托单位：
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  • 批准号：
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  • 项目类别：
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