Core C - Fieldwork Core

核心C现场工作-总结： 胃腺癌是全球癌症死亡率的第三大原因，也是感染的主要原因- 相关的癌症死亡率，具有明显的地理差异。在拉丁美洲， 这表现在“海拔之谜”上，尽管同样高的H。幽门螺杆菌感染率高， 在这些国家中，山区和沿海地区的发病率分别较低， 太平洋沿岸的地带。核心C建立在长期、富有成效且具有成本效益的研究之上 哥伦比亚和中美洲的基础设施，每一个都在高风险山区， 风险较低的沿海地区，包括种族和民族多样化的人口。田野调查 核心C代表实现本计划项目目标的中心。核心C将监督所有 在拉丁美洲开展的研究活动，并提供流行病学数据和人类 用于所有项目和核心的样本。我们的核心C具体目标是：（1）在哥伦比亚，执行所有 与哥伦比亚化学预防队列中受试者的监督和随访有关的活动， 关注那些沿着组织病理学级联进展的个体，从慢性胃炎到萎缩或 肠上皮化生和异型增生/腺癌。项目1、2和3的核心研究将侧重于 这群进步者。(2)在中美洲，履行与征聘新工作人员有关的职能 主题为中美洲横截面H.幽门螺杆菌和人类遗传祖先研究。三个网站 包括高风险山区（洪都拉斯科潘）和低风险沿海地区， 加勒比（洪都拉斯特拉）和太平洋（尼加拉瓜莱昂）。这将提供无与伦比的研究平台 对于拟议的遗传祖先研究，进一步检查和探索我们令人兴奋的 关于不一致的共同进化和胃癌风险的研究结果。(3)监督研究基础设施 在哥伦比亚和中美洲，包括数据管理、标本收集和生物储存库。 核心C将管理项目流行病学数据库，以协调与 项目和其他核心，提供全面的质量控制，并跟踪生物标本。核心C将确保所有 在哥伦比亚和中美洲，数据和标本在国内被去识别化。总之，哥伦比亚 在本计划项目的整个过程中，实地工作核心已经到位，我们现在将采用此P01 在一个令人兴奋的新方向，通过增加在中美洲建立的网站，提供一个无与伦比的平台， 我们提出的临床转化研究的机制，管理胃癌。

Core C FIELDWORK – Summary: Gastric adenocarcinoma is the third leading cause of global cancer mortality and the leading cause of infection- associated cancer mortality, with marked geographic variability. In Latin America, geographic variability is manifest by the “altitude enigma” where despite similarly high H. pylori infection rates, sharply contrasting high and low incidence rates are observed in the mountainous versus coastal regions, respectively, in the countries of the Pacific littoral zone. Core C is built upon long-standing, productive, and cost-effective research infrastructures in Colombia and Central America, each with sites in the high risk mountainous regions and lower risk coastal areas, and inclusive of populations that are racially and ethnically diverse. The Fieldwork Core C represents the epicenter to achieve the goals of this Program Project. Core C will oversee care of all the research activities carried out in Latin America, and provide the epidemiological data and human specimens to be used in all Projects and Cores. Our Core C specific aims are: (1) In Colombia, to execute all activities related to the oversight and follow-up of subjects in the Colombia chemoprevention cohort, with a focus on individuals who progress along the histopathology cascade, from chronic gastritis, to atrophy or intestinal metaplasia, and to dysplasia/adenocarcinoma. Studies central to Projects 1, 2, and 3 will focus on this group of progressors. (2) In Central America, to perform functions related to the recruitment of new subjects for the Central America cross-sectional H. pylori and human genetic ancestry study. The 3 sites include the high risk mountainous area (Copán, Honduras), and the low risk coastal sites located on the Caribbean (Tela, Honduras) and Pacific (León, Nicaragua). This will provide an unparalleled research platform for the proposed genetic ancestry study, to further examine and explore the generalizability of our exciting findings regarding discordant co-evolution and gastric cancer risk. (3) To oversee the research infrastructures in Colombia and Central America, including data management, specimen collection and the biorepository. Core C will manage the Program Project epidemiology database to coordinate the interactions with the Projects and other Cores, provide overall quality control, and to track biospecimens. Core C will ensure that all data and specimens are de-identified in-country, in Colombia and Central America. In summary, the Colombia Fieldwork Core has been in place throughout the course of this Program Project, and we will now take this P01 in an exciting new direction by adding established sites in Central America to provide an unparalleled platform for our proposed clinical translational investigations into the mechanisms that govern gastric carcinogenesis.