Research Core

该核心的主要目标是促进项目领导人的科学和学术进步。该核心旨在为项目负责人提供指导和/或帮助，以便他们在机构动物护理和使用委员会中导航，并访问大学赞助的核心设施和仪器，编辑协助（赠款和手稿写作）和生物统计协助（例如，实验设计、数据分析）。确保获得这些最先进的服务是支持项目领导人的研究工作和确保实现COBRE目标的关键。核心领导人将与项目领导人合作，以确定和消除任何可能阻碍研究或教师发展的障碍。 具体目标1。在现有的流式细胞术核心设施中建立多色流式细胞术能力。我们建议购买BD LSRFortessa细胞分析仪（BD Biosciences，富兰克林湖，NJ），并为仪器使用提供专家技术和管理监督。目前，所有COBRE项目都需要多色流式细胞术分析。该仪器满足了这些项目的需求，并通过显着增强多色流式细胞术分析来扩展现有核心设施的能力。技术和管理结构已经到位，并为UAMS和周边校园（阿肯色州儿童医院和研究所，位于小石城的阿肯色州大学，中央阿肯色州大学等）的研究人员提供专业，高质量的流式细胞术分析。 具体目标2。为项目负责人提供项目和教师发展所需的资源和支持。核心人员将在制定动物使用协议、撰写手稿和赠款申请以及生物统计分析方面向项目负责人提供直接援助，并将促进项目负责人使用现有的共享设施或资源。为了促进项目负责人的时间和资源的有效利用，以及UAMS校园内现有的设施和仪器，核心B将协助项目负责人通过UAMS的各个办公室确定和访问所需的资源和支持服务。这将消除可能限制生产力的障碍，并将提供项目领导者在整个职业生涯中使用的学习经验。

The primary objective of this core is to facilitate the scientific and academic advancement of Project Leaders. The core is designed to provide the Project Leaders with the guidance and/or assistance they need to navigate the Institutional Animal Care and Use Committee and to access university-sponsored core facilities and instrumentation, editorial assistance (with grant and manuscript writing), and biostatistical assistance (e.g., with experimental design, data analysis). Ensuring access to these state-of-the-art services is key to supporting the research efforts of the Project Leaders and ensuring that the objectives of the COBRE are met. The Core Leader will work with Project Leaders to identify and remove any banriers that might impede research or faculty development. Specific Aim 1. Establish multiple-color flow cytometry capabilities in the existing Flow Cytometry Core Facility. We propose to acquire a BD LSRFortessa cell analyzer (BD Biosciences, Franklin Lakes, NJ) and to provide expert technical and managerial oversight for instrument use. Multiple-color flow cytometry analysis currently is needed by all of the COBRE projects. This instrument meets the needs of those projects and expands the capabilities of the existing core facility by providing significant enhancement in multiple-color flow cytometry analysis. The technical and managerial structure is already in place and provides expert, high-quality flow cytometry analysis for investigators at UAMS and surrounding campuses (Arkansas Children's Hospital and Research Institute, University of Arkansas at Little Rock, University of Central Arkansas, and others). Specific Aim 2. Provide Project Leaders with resources and support needed for project and faculty development. Core personnel will provide Project Leaders with direct assistance in developing animal-use protocols, writing manuscripts and grant applications, and biostatistical analysis and will facilitate Project Leaders' use of existing shared facilities or resources. To facilitate efficient use of Project Leaders' time and resources, and of the facilities and instrumentation currently in place on the UAMS campus, Core B will assist the Project Leaders in identifying and accessing needed resources and support services available through the various offices at UAMS. This will remove barriers that could limit productivity, and it will provide learning experiences that Project Leaders will use throughout their careers.