Research Core

这个核心的主要目标是促进项目负责人的科学和学术进步。核心项目旨在为项目负责人提供他们所需的指导和/或援助，以适应机构动物保护和利用委员会，并获得大学赞助的核心设施和仪器、编辑援助(通过赠款和手稿写作)和生物统计援助(例如，实验设计、数据分析)。确保获得这些最先进的服务是支持项目负责人的研究努力并确保实现COBRE目标的关键。核心负责人将与项目负责人合作，确定并清除任何可能阻碍研究或教师发展的障碍。 具体目标1.在现有的流式细胞仪核心设施中建立多色流式细胞仪能力。我们建议收购一台BD LSRFortessa细胞分析仪(BD Biosciences，Franklin Lake，NJ)，并为仪器的使用提供专业的技术和管理监督。目前，所有的Cobre项目都需要多色流式细胞仪分析。该仪器满足了这些项目的需求，并通过在多色流式细胞仪分析方面提供显著增强，扩展了现有核心设施的能力。技术和管理结构已经到位，为UAMS和周围校园(阿肯色州儿童医院和研究所、阿肯色大学小石城分校、阿肯色大学中部分校等)的研究人员提供专业、高质量的流式细胞仪分析。 具体目标2。为项目负责人提供项目和教师发展所需的资源和支持。核心人员将在制定动物使用方案、撰写手稿和拨款申请以及生物统计分析方面向项目负责人提供直接援助，并将促进项目负责人利用现有的共享设施或资源。为了有效利用项目负责人的时间和资源，以及UAMS园区现有的设施和仪器，核心B将协助项目负责人确定和利用通过UAMS各办事处提供的所需资源和支助服务。这将消除可能限制生产率的障碍，并将提供项目负责人在其职业生涯中使用的学习经验。

The primary objective of this core is to facilitate the scientific and academic advancement of Project Leaders. The core is designed to provide the Project Leaders with the guidance and/or assistance they need to navigate the Institutional Animal Care and Use Committee and to access university-sponsored core facilities and instrumentation, editorial assistance (with grant and manuscript writing), and biostatistical assistance (e.g., with experimental design, data analysis). Ensuring access to these state-of-the-art services is key to supporting the research efforts of the Project Leaders and ensuring that the objectives of the COBRE are met. The Core Leader will work with Project Leaders to identify and remove any banriers that might impede research or faculty development. Specific Aim 1. Establish multiple-color flow cytometry capabilities in the existing Flow Cytometry Core Facility. We propose to acquire a BD LSRFortessa cell analyzer (BD Biosciences, Franklin Lakes, NJ) and to provide expert technical and managerial oversight for instrument use. Multiple-color flow cytometry analysis currently is needed by all of the COBRE projects. This instrument meets the needs of those projects and expands the capabilities of the existing core facility by providing significant enhancement in multiple-color flow cytometry analysis. The technical and managerial structure is already in place and provides expert, high-quality flow cytometry analysis for investigators at UAMS and surrounding campuses (Arkansas Children's Hospital and Research Institute, University of Arkansas at Little Rock, University of Central Arkansas, and others). Specific Aim 2. Provide Project Leaders with resources and support needed for project and faculty development. Core personnel will provide Project Leaders with direct assistance in developing animal-use protocols, writing manuscripts and grant applications, and biostatistical analysis and will facilitate Project Leaders' use of existing shared facilities or resources. To facilitate efficient use of Project Leaders' time and resources, and of the facilities and instrumentation currently in place on the UAMS campus, Core B will assist the Project Leaders in identifying and accessing needed resources and support services available through the various offices at UAMS. This will remove barriers that could limit productivity, and it will provide learning experiences that Project Leaders will use throughout their careers.