Identification of Inhibitors of Nrf2 Expression

项目亮点：筛选了完整的化合物库，并确定了一个先导化学型用于开发。为了提高活性，研究人员进行了药物化学研究，并进行了一些基于细胞的高级分析，以表征这些化合物的细胞活性和抗癌活性。

Project highlights: the full compound library was screened and a lead chemotype was identified for development. Medicinal chemistry was undertake to improve activity, and a number of advanced cell-based assays were pursued to characterize cellular and anticancer activity of these compounds. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.