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THE SYNTHESIS AND PRECLINICAL STUDIES OF NEW TREATMENTS FOR NEURODEGENERATIVE DISEASE, DIABETES MELLITUS, CONGESTIVE HEART FAILURE, ONCOLOGIC AND IMMUNOLOGIC DISEASES

THE SYNTHESIS AND PRECLINICAL STUDIES OF NEW TREATMENTS FOR NEURODEGENERATIVE DISEASE, DIABETES MELLITUS, CONGESTIVE HEART FAILURE, ONCOLOGIC AND IMMUNOLOGIC DISEASES
神经退行性疾病、糖尿病、充血性心力衰竭、肿瘤和免疫疾病新疗法的综合和临床前研究
批准号：
8930675
负责人：
CAROL E GREEN
金额：
$9.19万
依托单位：
SRI INTERNATIONAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
项目状态：
已结题
起止时间：
2014-09-12 至 2016-01-30
来源：
https://reporter.nih.gov/project-details/8930675
关键词：
AcetylcholinesteraseAlzheimer&aposs DiseaseBrainButyrylcholinesteraseClinical ProtocolsCongestive Heart FailureDiabetes MellitusDoseDrug EvaluationDrug TargetingElderlyEnzymesEvaluationFreezingImmune System DiseasesNeurodegenerative DisordersPhase I Clinical TrialsPlasmaSamplingStagingTartratesinhibitor/antagonistpreclinical studyresearch clinical testingvolunteer

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英文摘要
(-)-Bisnorcymserine (BNC) tartrate is a small synthetic compound developed within IRP, NIA, for the treatment of late stage Alzheimer’s disease has recently entered clinical evaluation. It is a brain penetrant selective reversible butyrylcholinesterase inhibitor. This Task Order relates to evaluation of the level of percent inhibition of the target enzymes butyryl- and acetylcholinesterase in frozen blood and plasma samples derived from the initial BNC Phase 1 clinical trial (BNC doses 20 mg orally and escalations thereof). These studies allow analysis of drug target engagement during the initial evaluation of the drug in healthy elderly volunteers under an approved clinical protocol.
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