Sexual Distress and Body Image Distress in Younger Breast Cancer Survivors

描述（由申请人提供）：本研究的目的是检查正念减压疗法对年轻乳腺癌幸存者性痛苦和身体形象相关痛苦症状的影响。与年轻乳腺癌幸存者的性行为有关的问题很普遍，并且经常在手术和辅助治疗后报告，导致该人群的性困扰和身体形象问题。该项目将建立在乳腺癌幸存者MBSR症状群试验1 R 01 CA 131080的资源和优势之上，该试验由NRSA申请的赞助商Lengacher博士进行，并将补充Lengacher博士研究的目标。对于本博士预科NRSA，将获得作为申办方R 01研究受试者的年轻临床人群的额外证据，以确定：（1）治疗后处于过渡期的年轻乳腺癌女性的心理和身体困扰水平;（2）基于正念的减压-乳腺癌的程度正念减压疗法（BC）作为一种减压计划，在改善与性有关的痛苦方面是有效的，即性痛苦和身体形象相关的痛苦;以及（3）与老年乳腺癌幸存者相比，年轻患者的这一亚组是否从正念减压疗法（BC）中获益最多。为了帮助了解性困扰和身体形象相关困扰的程度，因为它们影响了这一人群的生活质量，将采取两阶段研究方法。首先，在I期，将对参与R 01研究的21-54岁年轻乳腺癌幸存者的基线数据进行次要数据分析。第一阶段的具体目标是通过对R 01研究乳腺癌幸存者MBSR症状群试验中收集的数据进行二次分析，评估年轻女性的痛苦水平，包括抑郁、焦虑、对复发的恐惧、心理和身体痛苦以及生活质量。对于第2阶段，试点研究，也是论文研究的重点，将在赞助商R 01赠款的80名乳腺癌幸存者的亚组中实施。本初步研究的目的是：1）评价MBSR（BC）计划在改善性困扰和身体形象相关困扰沿着心理、身体症状和生活质量方面的疗效; 2）评价MBSR（BC）计划获得的积极效果是否会因基线时测量的特定患者特征而改变。由此产生的数据将提供一个更好的了解性困扰和身体形象相关的困扰，提供了一个基础，为未来的疾病预防和改善生活质量的妇女经历性困扰和身体形象相关的困扰，由于他们的乳腺癌治疗。预计这项研究的结果将提供进一步的发展或适应的具体干预措施，以改善症状管理，支持和教育的妇女在这一人口

DESCRIPTION (provided by applicant): The purpose of this research is to examine the impact of MBSR on the symptoms of sexual distress and body image related distress in younger breast cancer survivors. Problems related to sexuality in younger breast cancer survivors are prevalent and often reported following surgical and adjuvant treatment leading to sexual distress and body image issues in this population. This project will build upon the resources and strengths of the MBSR Symptom Cluster Trial for Breast Cancer Survivors, 1R01CA131080, which is being conducted by Dr. Lengacher, the sponsor of this NRSA application, and will complement the goals of Dr. Lengacher's study. For this Pre-doctoral NRSA, additional evidence in this younger clinical population who are subjects in the Sponsor's R01 study will be obtained to determine: (1) levels of psychological and physical distress in younger women with breast cancer in transition after treatment; (2) the extent to which the Mindfulness-Based Stress Reduction-Breast Cancer (MBSR (BC)) as a stress reducing program is efficacious in improving distress related to sexuality, i.e. sexual distress and body image related distress; and (3) if this subgrou of younger patients derive the most benefit from MBSR (BC) compared to older breast cancer survivors. To contribute to the limited knowledge regarding the extent of sexual distress and body image related distress as they impact the quality of life in this population, a two-phase study approach will be taken. First, in Phase 1, a secondary data analysis will be performed on baseline data of the younger breast cancer survivors, age 21-54 participating in the R01 study. The specific aim for Phase 1 is to assess the levels of distress among young women including depression, anxiety, fear of recurrence, psychological and physical distress, and quality of life through secondary analysis of data collected in the R01 study MBSR Symptom Cluster Trial for Breast Cancer Survivors. For Phase 2,a pilot study, also the focus of the dissertation research, will be implemented among a subgroup of 80 breast cancer survivors from the Sponsor's R01 grant. The aims for this pilot study will be to 1) evaluate the efficacy of the MBSR (BC) program in improving sexual distress and body image related distress along with psychological, physical symptoms and quality of life and 2) evaluate whether positive effects achieved from the MBSR (BC) program are modified by specific patient characteristics measured at baseline. Resulting data will provide a better understanding of sexual distress and body image related distress, providing a foundation for future disease prevention and improved quality of life in women experiencing sexual distress and body image related distress as a result of their breast cancer treatment. It is anticipated that the findings of this study will provide further development or adaptation of specific interventions appropriate for improved symptom management, support, and education for women in this population