Mouse Breeding and Procedure Core

核心C、小鼠育种和显微手术及程序核心将继续为所有三个项目提供服务 在该计划的所有五年中。Core C有两个主要功能：(1)小鼠的繁育和 管理股将继续提供培育成特定遗传背景的转基因和零基因小鼠 该计划的三个项目中的每一个。该单位将为动物提供交配和基因分型。 项目1-2-3需要。(2)新成立的小鼠显微手术和程序股已经成长为 该方案研究的扩展。该股的目标是使所有显微外科手术程序标准化 以及项目所执行的程序。这个单位将负责致命的辐射和骨骼 骨髓移植(方案2)，股动脉结扎诱导后肢缺血(方案2)， 评估胆固醇反向转运(项目1)和心肌梗死(项目3)。

Core C, the Mouse Breeding and Microsurgery and Procedure Core will continue to serve all three Projects over all five years of the Program. There are two major functions of Core C: (1) The Mouse Breeding & Management Unit will continue to provide transgenic and null mice bred Into specific genetic backgrounds to each of the three projects of the Program. This Unit will provide sen/ices to mate and genotype the animals required for Projects 1-2-3. (2) The newly-formed Mouse Microsurgery and Procedure Unit has grown out of the expansion of the Program's studies. The goal of this Unit is to standardize all microsurgery procedures and procedures carried out by the Projects. This Unit will be responsible for lethal irradiation and bone marrow transplantation (Projects 2), femoral artery ligation for induction of hind limb ischemia (Project 2), assessment of reverse cholesterol transport (Project 1) and myocardial infarction (Project 3).