Aspen Lung Conference: Rebuilding the Injured Lung

描述（由申请人提供）：第57届Thomas L. Petty Aspen年度肺脏会议强调基础、转化和临床方法的整合，将重点关注一个核心问题：我们如何将肺泡损伤机制的知识转化为重建损伤肺的有效方法？为了解决这一核心问题，我们将会议计划组织成一系列主题会议，重点关注(i)对急性和进行性肺损伤和纤维化的致病机制的当代理解，（ii）围绕肺上皮细胞、间充质细胞和周围细胞外结缔组织基质之间复杂相互作用的概念问题，（iii）目前对基质支架和干细胞生物学作为修复和重建受损肺的方法的理解，同时防止纤维化肺病的发生或进展；（iv）将科学进展转化为肺损伤和/或纤维化患者的潜在治疗方法的策略。通过在六个主题会议上讨论这些主题，我们寻求实现以下目标：1)为领先的基础，转化和临床研究人员提供一个国际论坛，以交流有关肺损伤，纤维化和修复的基本概念。2)促进历史上截然不同的急性肺损伤/ARDS和肺纤维化科学领域之间的互动，以确定可能导致更有效和更有成效的研究表现的新兴共同利益。3)通过制定新的策略，更好地将科学进展应用于患者护理，并解决临床试验设计中的挑战，提高临床前科学进展成功转化为直接患者利益的可能性。4)挑战和激发学员的科学兴趣，吸引新一代的初级研究者进入肺损伤与修复领域。

DESCRIPTION (provided by applicant): With an emphasis on the integration of basic, translational and clinical approaches, the 57th annual Thomas L. Petty Aspen Lung Conference will focus on a central question: how can we translate knowledge regarding the mechanisms underlying alveolar injury into effective approaches to rebuild the injured lung? To address this central question, we have organized the conference program into a series of thematic sessions focusing on (i) contemporary understanding of the pathogenic mechanisms underlying acute and progressive lung injury and fibrosis, (ii) conceptual issues centering around the complex interactions between pulmonary epithelial cells, mesenchymal cells, and the surrounding extracellular connective tissue matrix, (iii) current understanding of matrix scaffolds and stem cell biology as approaches to repairing and rebuilding the injured lung, while preventing the development or progression of fibrotic lung disease, and (iv) strategies to translate scientific advances into potential therapies for patients with lung injury and/or fibrosis. By addressing these topics across six thematic sessions, we seek to accomplish the following objectives: 1) To provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding fundamental concepts contributing to lung injury, fibrosis, and repair. 2) To stimulate interactions between the historically-disparate scientific fields of Acute Lung Injury/ARDS and Pulmonary Fibrosis with the goal of identifying emerging, shared interests that may lead to the performance of more efficient and productive research. 3) To enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better implement scientific advances into patient care and by addressing challenges in clinical trial design. 4) To challenge and stimulate the scientific interests of trainees, attracting a new generation of junior investigators into the fields of lung injury and repair.