Aspen Lung Conference: Rebuilding the Injured Lung

阿斯彭肺会议：重建受伤的肺

• 批准号: 8711900
• 负责人: David W. Riches
• 金额: $ 2万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711900
• 关键词: Acute; Acute Lung Injury; Address; Adult Respiratory Distress Syndrome; Alveolar; Cells; Clinical; Clinical Investigator; Clinical Trials Design; Collaborations; Complex; Connective Tissue; Development; Epithelial Cells; Fibrosis; Fostering; Generations; Goals; Injury; International; Knowledge; Lead; Lung; Lung Inflammation; Lung diseases; Mediating; Mesenchymal; Patient Care; Patients; Performance; Pulmonary Fibrosis; Research; Research Personnel; Scientific Advances and Accomplishments; Scientist; Series; Stem cells; Translating; Translations; extracellular; improved; injured; interest; lung injury; lung repair; meetings; novel strategies; pre-clinical; prevent; programs; public health relevance; repaired; scaffold; stem cell biology; success; symposium

DESCRIPTION (provided by applicant): With an emphasis on the integration of basic, translational and clinical approaches, the 57th annual Thomas L. Petty Aspen Lung Conference will focus on a central question: how can we translate knowledge regarding the mechanisms underlying alveolar injury into effective approaches to rebuild the injured lung? To address this central question, we have organized the conference program into a series of thematic sessions focusing on (i) contemporary understanding of the pathogenic mechanisms underlying acute and progressive lung injury and fibrosis, (ii) conceptual issues centering around the complex interactions between pulmonary epithelial cells, mesenchymal cells, and the surrounding extracellular connective tissue matrix, (iii) current understanding of matrix scaffolds and stem cell biology as approaches to repairing and rebuilding the injured lung, while preventing the development or progression of fibrotic lung disease, and (iv) strategies to translate scientific advances into potential therapies for patients with lung injury and/or fibrosis. By addressing these topics across six thematic sessions, we seek to accomplish the following objectives: 1) To provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding fundamental concepts contributing to lung injury, fibrosis, and repair. 2) To stimulate interactions between the historically-disparate scientific fields of Acute Lung Injury/ARDS and Pulmonary Fibrosis with the goal of identifying emerging, shared interests that may lead to the performance of more efficient and productive research. 3) To enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better implement scientific advances into patient care and by addressing challenges in clinical trial design. 4) To challenge and stimulate the scientific interests of trainees, attracting a new generation of junior investigators into the fields of lung injury and repair.

描述（由申请人提供）：第57届年度托马斯L。Petty白杨肺会议将集中讨论一个中心问题：我们如何将肺泡损伤机制的知识转化为重建受损肺的有效方法？为了解决这个中心问题，我们将会议计划组织成一系列主题会议，重点是（i）对急性和进行性肺损伤和纤维化的致病机制的当代理解，（ii）围绕肺上皮细胞，间充质细胞和周围细胞外结缔组织基质之间复杂相互作用的概念问题，（iii）目前对基质支架和干细胞生物学的理解，作为修复和重建受损肺的方法，同时防止纤维化肺病的发展或进展，以及（iv）将科学进步转化为肺损伤和/或纤维化患者的潜在疗法的策略。通过在六个专题会议中讨论这些主题，我们寻求实现以下目标：1）为领先的基础，转化和临床研究人员提供一个国际论坛，以交流有关肺损伤，纤维化和修复的基本概念的想法。2)刺激急性肺损伤/ARDS和肺纤维化的历史不同的科学领域之间的互动，以确定新兴的，共同的利益，可能导致更有效和富有成效的研究性能的目标。3)通过制定新的策略，更好地将科学进步应用于患者护理，并解决临床试验设计中的挑战，提高临床前科学进步成功转化为直接患者受益的可能性。4)挑战和激发学员的科学兴趣，吸引新一代的初级研究人员进入肺损伤和修复领域。