qHTS to Identify Inducers of Oligodendrocyte-precursor cell (OPC) Remyelination

qHTS 鉴定少突胶质细胞前体细胞 (OPC) 髓鞘再生诱导剂

• 批准号: 9205679
• 负责人: Matthew Hall
• 金额: $ 1.9万
• 依托单位: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9205679
• 关键词: qHTS; Identify; Inducers; Oligodendrocyte; precursor

Project highlights: small targeted libraries have been screened to identify potential repurposing leads, and advanced cell-based models are being undertaken to fully characterize potent actives. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.

项目亮点：已经筛选了小的靶向文库，以确定潜在的再利用线索，并且正在采用先进的基于细胞的模型来充分表征有效的活性物质。 在此期间，NCGC促进并保持了与NIH和校外研究人员的180多项积极合作，促进了整个人类疾病谱的药物发现工作。 这些努力已经导致了100多个高通量筛选和近60个药物化学活动，为我们的合作者和一般研究社区提供了丰富的出版物和有前途的小分子线索。 此外，NCGC还承担了一系列信息挑战，以更好地利用现有的药物和疾病靶点信息，并为公众提供易于获取的资源，进一步促进人类疾病新疗法的开发。