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Eval. of Minocycline as a Microglia Inhibitor in Tx of Diabetic Macular Edema

Eval. of Minocycline as a Microglia Inhibitor in Tx of Diabetic Macular Edema
评估。
批准号：
9155595
负责人：
Catherine Cukras
金额：
$6.11万
依托单位：
NATIONAL EYE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9155595
关键词：
Anti-Inflammatory AgentsAnti-inflammatoryBlindnessCaringChronicData AnalysesDiabetic RetinopathyGenerationsInflammationInflammatoryLasersMediationMicrogliaMinocyclineNeuronsPatientsPilot ProjectsProcessPropertyRetinaRetinalSafetySiteTetracyclinesUnited Statesantimicrobialcellular targetingdiabeticinhibitor/antagonistmacular edemaprospective

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中文摘要
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英文摘要
There is accumulating evidence that retinal microglia are indeed associated with diabetic retinopathy. Minocycline is a second-generation tetracycline, which has anti-inflammatory properties that are separate from its anti-microbial properties. The study objective is to investigate the safety and efficacy of minocycline, a microglia inhibitor, in the treatment of diabetic macular edema. This is a prospective, non-randomized, uncontrolled, single group, single center pilot study to investigate the safety and efficacy of minocycline as a microglia inhibitor in patients with DME who have already been treated with standard-of-care laser or who are not amenable to standard-of-care therapy. The study has ended but we continue to analyze the data.
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Eval. of Minocycline as a Microglia Inhibitor in Tx of CRVO and BRVO
  • 批准号：
    8737681
  • 项目类别：
  • 资助金额：
    $15.84万
  • 财政年份：
    --
  • 负责人：
    Catherine Cukras
  • 依托单位：
    NATIONAL EYE INSTITUTE
Longitudinal Investigation of Dark Adaptation in Participants with AMD
  • 批准号：
    8737669
  • 项目类别：
  • 资助金额：
    $14.18万
  • 财政年份：
    --
  • 负责人：
    Catherine Cukras
  • 依托单位：
    NATIONAL EYE INSTITUTE
Longitudinal Investigation of Dark Adaptation in Participants with AMD
  • 批准号：
    8556871
  • 项目类别：
  • 资助金额：
    $13.64万
  • 财政年份：
    --
  • 负责人：
    Catherine Cukras
  • 依托单位：
    NATIONAL EYE INSTITUTE
Eval. of Minocycline as a Microglia Inhibitor in Tx of CRVO and BRVO
  • 批准号：
    9155610
  • 项目类别：
  • 资助金额：
    $29.38万
  • 财政年份：
    --
  • 负责人：
    Catherine Cukras
  • 依托单位：
    NATIONAL EYE INSTITUTE
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