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Antibodies for Characterizing the Structure and Function of Proteases

Antibodies for Characterizing the Structure and Function of Proteases
用于表征蛋白酶结构和功能的抗体
批准号:
8702411
负责人:
Charles Scott Craik
金额:
$34.26万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-24 至 2019-08-31

项目摘要

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中文摘要
翻译
意义:蛋白酶占蛋白质的2%
英文摘要
Significance: Proteases make up 2% of the human proteome (3), and their functional activity is a unique, irreversible post-translational modification of their target substrates (7). Proteases are involved in a number of important physiological functions from blood coagulation to digestion and pathophysiological activities necessary for activation and propagation of cancer cascades and Alzheimer's disease (8). More information about protease biology and pathophysiology in addition to new selective therapeutics would be important for understanding and treating human disease.
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会议论文
Developing Antivirals Targeting Proteases and Polymerases of Coronaviruses, Picornaviruses and Bunyavirales
New radiotracer development to study immune cell mobilization of granzyme proteolytic activity
New radiotracer development to study immune cell mobilization of granzyme proteolytic activity
New radiotracer development to study immune cell mobilization of granzyme proteolytic activity
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