Antibodies for Characterizing the Structure and Function of Proteases
Antibodies for Characterizing the Structure and Function of Proteases
批准号:
8702411
负责人:
Charles Scott Craik
金额:
$34.26万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-24 至 2019-08-31
中文摘要
意义:蛋白酶占蛋白质的2%
英文摘要
Significance: Proteases make up 2% of
the human proteome (3), and their functional activity is a unique, irreversible post-translational modification of their target substrates (7). Proteases are involved in a number of important physiological functions from blood coagulation to digestion and pathophysiological activities necessary for activation and propagation of cancer cascades and Alzheimer's disease (8). More information about protease biology and pathophysiology in addition to new selective therapeutics would be important for understanding and treating human disease.
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会议论文
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Probing the Role of Chaperone-TPR Complexes in Tau Proteostasis
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批准号:10029781
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Non-invasive Differentiation of Benign Lesions from Aggressive Pancreatic Cancer
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Extracellular Proteolysis as a Molecular Stratification Tool for Cancer
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Allosteric Inhibition of a Family of Proteolytic Enzymes
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批准号:8577916
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资助金额:$30.38万
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财政年份:2013
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依托单位:
Allosteric Inhibition of a Family of Proteolytic Enzymes
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批准号:8698774
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资助金额:$30.52万
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财政年份:2013
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Allosteric Inhibition of a Family of Proteolytic Enzymes
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批准号:9039629
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财政年份:2013
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依托单位:
CHARACTERIZATION COVALENT INHIBITORS OF SERINE, CYSTEINE & ASPARTYL PROTEINASE
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批准号:8363756
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A Technological Platform for the Identification of Serine Proteases in Cancer
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批准号:7895790
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资助金额:$35.47万
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A Technological Platform for the Identification of Serine Proteases in Cancer
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资助金额:$34.15万
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TARGETTING CYSTEINE PROTEINASES OF THE SARS-ASSOCIATED CORONAVIRUS
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财政年份:2009
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CHARACTERIZATION COVALENT INHIBITORS OF SERINE, CYSTEINE & ASPARTYL PROTEINASE
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A Technological Platform for the Identification of Serine Proteases in Cancer
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TARGETTING CYSTEINE PROTEINASES OF THE SARS-ASSOCIATED CORONAVIRUS
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财政年份:2008
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CHARACTER COVALENT INHIBITORS OF SERINE, CYSTEINE & ASPARTYL PROTEINASE: HIV
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Targeting Allosteric Studies to Modulate Protein Interactions and Function
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依托单位:
国内基金
海外基金
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依托单位:
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