The Georgians Organized Against Lupus (GOAL) Cohort: Advancing Health Disparities

格鲁吉亚人组织抗狼疮 (GOAL) 队列：扩大健康差距

• 批准号: 8897875
• 负责人: Cristina Marta Drenkard
• 金额: $ 99.96万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8897875
• 关键词: Georgians; Organized; Against; Lupus; GOAL

DESCRIPTION (provided by applicant): Limitations in the ability to assemble large population-based cohorts of patients with systemic and/or cutaneous lupus with validated diagnoses and with significant representation from previously underrepresented socio-demographic groups have been a significant barrier to better understanding the true clinical burden of lupus, as well as the many unanswered questions related to treatment, health care access, and natural history. The Georgia Lupus Registry (GLR) is one of two recently completed Centers for Disease Control and Prevention-funded population-based lupus registries designed to minimize many of these limitations. The Georgians Organized Against Lupus (GOAL) Cohort was born out of the efforts of the GLR to create a population-based prospective cohort of validated and consented SLE patients, reflecting "real world" lupus in the community in and around Atlanta, Georgia. Since its inception, 802 lupus patients have been consented and finished enrollment in the first year (2011-2012) and a total of 929 SLE patients by the end of the second year (2013). It is also uniquely positioned to create the largest population-based cohort of cutaneous lupus in the US. Our proposal is completely responsive to all of the special eligibility requirements of thi FOA and will utilize the established GOAL Cohort to prospectively collect important information and biological materials to serve as a repository for hypothesis generation and investigation by qualified research groups. This powerful and unique collection of patients followed over time will also provide an opportunity to explore important areas that were not possible before. Our proposal will utilize an established population-based lupus cohort to prospectively collect important information and biological materials to serve as a repository for hypothesis generation and investigation by qualified research groups. This powerful and unique collection of patients followed over time will also provide an opportunity to explore important areas that were not possible before. Specifically, we propose 2 projects that will explore how important and innovative components of social determinants of health interact with clinical, socioeconomic, and/or biologic factors to influence cardiovascular disease outcomes in systemic lupus erythematosus and quality of life in cutaneous lupus erythematosus as a way of understanding and addressing the significant racial health disparities that continue to exist. A third project wil use innovative laboratory platforms to test our ability to better predict those who are at highest risk of disease flares, potentially further mitigating disparities in the burden of disease. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

描述（由申请人提供）：收集系统性和/或皮肤性狼疮患者的大规模人群队列的能力受到限制，这些患者具有经过验证的诊断，并且具有以前未被充分代表的社会人口统计学群体的显著代表性，这是更好地了解狼疮真正临床负担的重大障碍，以及与治疗、医疗保健获取和自然史相关的许多未解决的问题。乔治亚狼疮登记处（GLR）是最近完成的两个疾病控制和预防中心资助的以人群为基础的狼疮登记处之一，旨在最大限度地减少这些限制。乔治亚州组织对抗狼疮（GOAL）队列研究是在GLR的努力下诞生的，目的是创建一个基于人群的前瞻性队列研究，研究对象是经过验证和同意的SLE患者，反映佐治亚州亚特兰大及其周边社区的“真实世界”狼疮。自试验开始以来，第一年（2011-2012年）有802例狼疮患者同意并完成入组，到第二年（2013年）年底，共有929例狼疮患者同意并完成入组。它也具有独特的定位，以创建美国最大的基于人群的皮肤狼疮队列。我们的提案完全符合本FOA的所有特殊资格要求，并将利用已建立的GOAL队列前瞻性地收集重要信息和生物材料，作为合格研究小组产生假设和调查的存储库。随着时间的推移，这些强大而独特的患者集合也将为探索以前不可能的重要领域提供机会。我们的建议将利用一个已建立的以人群为基础的狼疮队列，前瞻性地收集重要信息和生物材料，作为假设生成和合格研究小组调查的存储库。随着时间的推移，这些强大而独特的患者集合也将为探索以前不可能的重要领域提供机会。具体来说，我们提出了两个项目，将探索健康的社会决定因素的重要和创新组成部分如何与临床、社会经济和/或生物学因素相互作用，影响系统性红斑狼疮的心血管疾病结局和皮肤红斑狼疮的生活质量，作为理解和解决持续存在的重大种族健康差异的一种方式。第三个项目将使用创新的实验室平台来测试我们更好地预测疾病爆发风险最高人群的能力，从而有可能进一步减轻疾病负担方面的差异。小灵通398/2590 （Rev. 06/09）页延续格式页