Investigation of SYD-1 function in axon guidance.

SYD-1 轴突引导功能的研究。

• 批准号: 8872008
• 负责人: CHRISTOPHER C QUINN
• 金额: $ 7.48万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8872008
• 关键词: Axon; Biochemical; Caenorhabditis elegans; Cues; Data; Development; Diagnosis; Event; Failure; Genetic; Goals; Guanosine Triphosphate Phosphohydrolases; Investigation; Knowledge; Lead; Mediating; Mental disorders; Nervous system structure; Neurons; Process; Receptor Signaling; Regulation; Relative (related person); Research; Role; Series; Signal Pathway; Signal Transduction; System; Testing; axon growth; axon guidance; combinatorial; developmental disease; extracellular; genetic analysis; insight; interest; nervous system disorder; protein function; public health relevance; receptor; response; rho GTPase-activating protein

 DESCRIPTION (provided by applicant): Axons are guided through the developing nervous system by directional responses to extracellular guidance cues. The axon is simultaneously exposed to multiple guidance cues and must integrate this information to provide a unified response. Much progress has been made in identifying receptors and signaling pathways. However, much less is known about how the axon integrates information from the different guidance signaling pathways. Our preliminary data implicate SYD-1 in axon guidance. We will test the hypothesis that SYD-1 can mediate UNC-6 independent UNC-40 signaling to promote the response to the SLT-1 guidance cue. In addition, we will characterize the mechanism through which SYD-1 regulates axon guidance. Support for our hypothesis would be significant because it would provide a mechanism for crosstalk between the UNC-40 and SAX-3 signaling pathways, thereby providing insight into how information between guidance signaling pathways can be integrated.

 描述（由申请人提供）：轴突通过对细胞外引导线索的定向反应被引导通过发育中的神经系统。轴突同时暴露于多个引导线索，必须整合这些信息以提供统一的反应。在识别受体和信号通路方面已经取得了很大进展。然而，关于轴突如何整合来自不同指导信号通路的信息，我们知之甚少。我们的初步数据表明SYD-1参与了轴突导向。我们将测试SYD-1可以介导独立于UNC-6的UNC-40信号传导以促进对SLT-1引导线索的反应的假设。此外，我们将描述SYD-1调节轴突导向的机制。支持我们的假设将是重要的，因为它将提供一个机制，串扰之间的α-40和SAX-3信号通路，从而提供洞察如何指导信号通路之间的信息可以整合。