Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network

描述（由申请人提供）：本提案的目的是支持NIH NHLBI预防和早期治疗急性肺损伤（PETAL）网络的运行>该网络的目标是有效地测试药物、设备和方案，以预防和治疗早期急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS），从而改善患者的短期和长期结局。为了实现这一目标，研究人员将： 1.为指导委员会和小组委员会提供组织领导，以建立有序、合理的流程，以开发、选择和开展至少两项临床试验，并完善网络的结构和操作程序。 2.在假设的生成，方案的开发，以及招募和数据收集技术和方法的完善，以获取和分析临床数据和样本方面进行合作。这项工作将包括收集高质量的生物和遗传标本，使网络成员和网络外的其他人能够研究急性肺损伤的基因组学、蛋白质组学和微生物组学。 3.在5年半的时间里，招募至少220名具有性别和种族代表性的受试者参加临床试验，以生成高质量数据来检验指导委员会提出的假设。 4.通过高知名度的科学出版物和演示文稿传播研究结果。

DESCRIPTION (provided by applicant): The objective of this proposal is to support the operation of the NIH NHLBI prevention and early treatment of acute lung injury (PETAL) Network> The Network's goal is to efficiently test drugs, devices, and protocols to prevent and treat early acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) thereby improving the short and long-term outcomes of patients. To achieve this goal the investigators will: 1. Provide organizational leadership to a Steering Committee and Subcommittees to establish an orderly, rational, process to develop, select, and conduct at least two clinical trials and to refine the Network's structure, and operating procedures. 2. Collaborate in the generation of hypotheses, development of protocols, and refinement of recruitment and data collection techniques and methods to acquire and analyze clinical data and samples. This effort will include collection of high quality biological and genetic specimens to allow Network members and others outside the network to study the genomics, proteomics and microbiome of acute lung injury. 3. Over 5.5 years recruit a minimum of 220, gender and ethnically representative subjects to clinical trials to generate quality data to test hypotheses posed by the Steering Committee. 4. Disseminate study results through high profile scientific publications and presentations.