Clinical-Experimental Tissue Resource (ETR)

CORE 007-临床-项目摘要/摘要-实验组织资源(ETR) 实验组织共享资源(ETR)的主要目标是提供基本的、翻译的和 癌症中心的临床研究人员获取并分析人类和动物组织。一把钥匙 优势是这个核心利用了病理学系的技术和专业知识 和检验医学。目前提供四条服务线路：1)组织采购和解释 组织病理学咨询，2)组织组织学和IHC服务，3)激光捕获显微解剖，4) 老鼠病理服务。在上一个完整的资助期内，有69个CFCCC成员使用了ETR服务，以及 比上一个五年期资助期增加10%。已向15个客户提供合作意向书 以癌症为重点的拨款提案，6名初级教员接受了关于开发组织的指导 采购或分析的目的在赠款提案中。组织学部分提供了高质量的服务 低于市场充值率，CFCCC成员主要追求较短的周转时间 人类癌症标本的翻译研究或研究人类癌症的动物模型。这些 这些特点使我们的组织学服务优于商业供应商提供的服务，有助于 使用量增长。在过去5年中，ETR服务贡献了来自36个不同CFCCC的58份出版物 首席调查员。解释性组织病理学服务对调查人员来说特别有价值 从事翻译和临床研究项目。在即将到来的资金期，优先发展 服务包括更新组织银行的IRB和预期知情同意程序，添加 用于收集骨髓抽吸物的冷冻存储空间和标本处理能力；以及 实施新的数据管理工具，用于研究的接收、库存、QC/QA和支付 纸巾。

Core 007 - Clinical - Project Summary/Abstract - Experimental Tissue Resource (ETR) The primary objective of the Experimental Tissue Shared Resource (ETR) is to provide basic, translational, and clinical researchers within the Cancer Center access to, and analysis of, human and animal tissues. A key advantage is that this Core leverages the technical and professional expertise of the Department of Pathology and Laboratory Medicine. Four service lines are currently offered: 1) Tissue Procurement and Interpretive Histopathology Consultation, 2) Tissue Histology and IHC services, 3) Laser Capture microdissection, and 4) Mouse Pathology services. In the prior full funding period, 69 CFCCC Members have used ETR services, an increase of 10% over the prior 5-year funding period. Fifteen clients have been provided letters of collaboration for cancer-focused grant proposals, and 6 junior faculty members have been mentored with regard to developing tissue procurement or analysis aims in grant proposals. The histology component has provided high-quality service at below-market recharge rates, with short turn-around times for CFCCC members who are mainly pursuing translational research on human cancer specimens or studying animal models of human cancer. These features have made our histology services superior to those available from commercial vendors, contributing to usage growth. ETR services contributed to 58 publications in the previous 5 years, from 36 different CFCCC Principal Investigators. Interpretive histopathology services have been particularly valuable to investigators pursuing translational and clinical research projects. In the coming funding period, priorities for growing the service include updating the IRB and prospective informed consent process for tissue banking, adding cryostorage space and specimen processing capabilities for bone marrow aspirate collection, and implementing new data management tools for the intake, inventory, QC/QA, and disbursement of research tissues.