RECQ2016 - Partnering for Progress

RECQ2016 - 合作共进

• 批准号: 9122070
• 负责人: RAYMOND J MONNAT
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9122070
• 关键词: Address; Affect; Age; Aging; Area; Award; Basic Science; Biology; Caregivers; Cells; Clinical Research; Clinical Sciences; DNA; Development; Disease; Education; Family; Family Caregiver; Family member; Fostering; Foundations; Fred Hutchinson Cancer Research Center; Future; Genome Stability; Goals; Health; Human; Human Biology; Human Genome; Individual; International; Knowledge; Link; Malignant Neoplasms; Medicine; Metabolism; Mining; Mission; Participant; Pathogenesis; Patient Care; Patient Education; Patients; Phenotype; Physiological; Play; Positioning Attribute; Predisposition; Proteins; Research; Research Personnel; Research Priority; Research Support; Role; Rothmund-Thomson syndrome; Science; Scientist; Structure; Study models; Support Groups; Syndrome; Training; Translational Research; Travel; Update; Work; abstracting; cancer type; clinical care; empowerment; fascinate; helicase; high risk; human DNA; human disease; improved; interest; loss of function; meetings; posters; programs; public health relevance; symposium

 DESCRIPTION (provided by applicant) Abstract: This application is to support the 3rd International Meeting on RECQ Helicases in Biology and Disease, titled 'RECQ2016 - Partnering for Progress', to be held at the Fred Hutchinson Cancer Research Center in Seattle, WA from Saturday 28 May to Monday 30 May 2016. The RECQ helicases play important roles in many aspects of human DNA metabolism and genomic stability, and are linked to Bloom, Werner and Rothmund- Thomson syndromes that all share a strong cancer predisposition. Goals: Our meeting goals are to improve understanding of RECQ helicase function in human cells; to deter- mine how the loss of RECQ function promotes cancer and other associated phenotypes; and to identify top clinical and research priorities to foster RECQ basic and translational research and improve clinical care. Aims: We will achieve our goals by addressing each of the following Aims/focus areas: Aim 1: Understand function and disease pathogenesis Aim 2: Develop research partnerships Aim 3: Identify research priorities Aim 4: Education - focused on patients, families and caregivers Aim 5: Training - focused on junior and new investigators and on clinicians Program Structure: We will convene 35 speakers/panelists, patients, family members, care givers and foundation/support groups for three focused and highly interactive days. There will be concurrent scientific presentations and Family meetings, with shared keynote talks, poster preview and poster sessions and panels. Significance: This conference is uniquely positioned to catalyze research by bringing together investigators focused on RECQ biology and disease with patients, families and caregivers. We aim to integrate basic and clinical science and incorporate the unique perspective of patients, families and caregivers in developing priorities for future work. Health relatedness: This meeting reflects the growing importance of RECQ helicases in human biology and disease, and the need to better understand the mechanistic origins of the RECQ helicase syndromes to understand disease associations and improve clinical care.

 描述(由申请人提供)摘要：本申请旨在支持第三届生物和疾病中的RecQ螺旋酶国际会议，该会议将于2016年5月28日星期六至5月30日星期一在华盛顿州西雅图的弗雷德·哈钦森癌症研究中心举行，主题为‘RECQ2016-Partnering for Progress’。RecQ解旋酶在人类DNA新陈代谢和基因组稳定性的许多方面发挥着重要作用，并与Bloom、Werner和Rothmund-Thomson综合征有关，这些综合征都有很强的癌症易感性。目标：我们的会议目标是增进对RecQ解旋酶在人类细胞中的功能的了解；阻止RecQ功能的丧失如何促进癌症和其他相关表型；并确定首要的临床和研究优先事项，以促进RecQ基础和翻译研究并改善临床护理。目标：我们将通过解决以下目标/重点领域来实现我们的目标：目标1：了解功能和疾病发病机制目标2：发展研究伙伴关系目标3：确定研究优先事项目标4：以患者、家庭和护理人员为重点的教育目标5：以初级和新研究人员以及临床医生为重点的培训计划结构：我们将召集35演讲者/小组成员、患者、家庭成员、护理人员和基金会/支持小组进行为期三天的集中和高度互动。将同时举行科学报告和家庭会议，分享主题演讲、海报预览和海报会议和小组讨论。意义：这次会议的独特之处在于，通过将专注于RecQ生物学和疾病的研究人员与患者、家人和护理人员聚集在一起，促进研究。我们的目标是将基础科学和临床科学结合起来，并在制定未来工作的优先事项时纳入患者、家庭和护理人员的独特视角。与健康相关：这次会议反映了RecQ解旋酶在人类生物学和疾病中日益重要，以及需要更好地了解RecQ解旋酶综合征的机制起源，以了解疾病关联和改善临床护理。