Exposure Assessment Facility Core

总结/摘要（暴露评估核心） 暴露评估核心（EAC）提供关键支持，以推进M-LEEaD使命， 为M-LEEaD科学家提供广泛的暴露评估服务。选管会进行风险分析 在试点项目中，促进环境的设计、执行、分析和定性， 曝光，并扩大了曝光测量的使用和能力。选管会协助确保 中心研究者生成和使用的暴露评估和分析数据在科学上是合理的， 质量有保证，并反映了最先进的知识和专业知识。EAC还进一步推动了 通过参与旨在为政策提供信息的外联和翻译举措， 外行公众。具体目标是：（1）提供分析服务，以测量和表征 （2）提供咨询、转诊和医疗服务; 以及支持中心成员暴露评估活动的其他服务;（3）协调和 利用与生物监测有关的暴露评估活动;（4）提供统计和建模分析 （5）提高曝光测量的性能和能力;以及（6） 向中心研究者传播暴露评估相关信息，并向公众宣传， 其他利益攸关方。选管会旨在采用创新的方法，包括采用新的和增强的 取样和分析方法。核心管理和活动鼓励利用东非共同体， 制定试点项目和建议，并开展研究。使用混合成本模型， 提供免费咨询，获得广泛的服务菜单，以及“一站式”购物方式， 利用暴露测量、提高研究生产力和促进跨学科工作的目标 为M-LEEaD成员和其他从事环境健康科学研究的人提供服务。进入选管会是 提供给M-LEEaD成员，密歇根大学的科学家和其他研究人员。成本匹配和 M-LEEaD成员可享受分析服务的折扣费用，具体取决于分析物、基质和 的服务.东非共同体的资金在必要和可行的情况下帮助支持方法制定、统计分析， 暴露建模和数据解释，即，这些项目不向中心会员收费。东非共同体基金 还帮助扩大试点项目，启动和支持方法开发和探索工作，并促进 与合作和支持实验室一起参与实验室间质量比较 保证和其他目的。方法制定活动，支持 中心成员专注于推进生物标志物测量，包括使用先进的LC/MS-MS 方法，使用存档的干血点样本增强化学检测和验证，以及 组合基因组/生物标志物优化。

SUMMARY/ABSTRACT (Exposure Assessment Core) The Exposure Assessment Core (EAC) provides critical support to advance the M-LEEaD mission through a broad range of exposure assessment services for M-LEEaD scientists. The EAC conducts exposure analyses in pilot projects, facilitates the design, implementation, analysis and characterization of environmental exposures, and expands the use and capabilities of exposure measurements. The EAC helps to ensure that exposure assessments and analytical data generated and used by center investigators are scientifically sound, quality-assured, and reflect state-of-the-art knowledge and expertise. The EAC also furthers the translational initiatives of the center by participating in outreach and translational initiatives aimed at informing policy and the lay public. The specific aims are to: (1) provide analytical services to measure and characterize environmental exposures for research investigating exposure-disease links; (2) provide consultations, referrals and other services that support exposure assessment activities for center members; (3) coordinate and leverage exposure assessment activities related to biomonitoring; (4) provide statistical and modeling analyses for exposure data; (5) advance the performance and capability of exposure measurements; and (6) disseminate exposure assessment related information to center investigators and outreach to the public and other stakeholders. The EAC aims to use innovative methods, including the use of novel and enhanced sampling and analytical methods. Core management and activities encourage utilization of the EAC in developing pilot projects and proposals and in executing research. Using a hybrid cost model, the core provides free consultations, access to a broad menu of services, and “one-stop” shopping approach with the goal of utilizing exposure measurements, enhancing research productivity, and promoting interdisciplinary work for M-LEEaD members and others engaged in environmental health sciences research. Access to the EAC is available to M-LEEaD members, University of Michigan scientists, and other investigators. Cost-matching and discounted fees for analytical services are available to M-LEEaD members, depending on analyte, matrix and service. EAC funds help support, as needed and feasible, methods development, statistical analyses, exposure modeling and data interpretations, i.e., these items are not charged to center members. EAC funds also help augment pilot projects, initiate and support method development and exploratory work, and promote participation with collaborating and supporting laboratories for inter-laboratory inter-comparisons for quality assurance and other purposes. Method development activities supporting exposure assessment activities of center members focus on advancing biomarker measurements, including the use of advanced LC/MS-MS approaches, enhanced chemical detection and validation using archived dried blood spots samples, and combined genome/biomarker optimization.