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Immunotoxins based on the IgG response to autologous antigens in cancer patients

Immunotoxins based on the IgG response to autologous antigens in cancer patients
基于癌症患者对自体抗原的 IgG 反应的免疫毒素
批准号：
9101634
负责人：
SCOTT Kendall DESSAIN
金额：
$19.9万
依托单位：
LANKENAU INSTITUTE FOR MEDICAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-04-01 至 2018-03-31
来源：
https://reporter.nih.gov/project-details/9101634
关键词：
AddressAffinityAmino AcidsAntibodiesAntibody ResponseAntibody-drug conjugatesAntigen TargetingAntigensAspergillusAutoantigensB lymphocyte immortalizationB-LymphocytesBacterial ToxinsBindingBiodistributionCancer EtiologyCancer PatientCancer cell lineCell LineCell surfaceCellsCessation of lifeCharacteristicsClinicalCloningColon CarcinomaComputer SimulationDevelopmentDoseDrug KineticsGPA33 geneGenerationsHumanHybrid CellsImmune systemImmunoglobulin GImmunoprecipitationImmunotoxinsIn VitroLifeMalignant NeoplasmsMalignant neoplasm of lungMeasuresMethodsModelingMoldsMonoclonal AntibodiesMusMutateMycotoxinsNeoplasm MetastasisNon-Small-Cell Lung CarcinomaNormal CellPatientsPerformancePersonal CommunicationPhenotypeProcessProtein IsoformsProteinsRNA SplicingRecombinantsResearchSafetySolid NeoplasmSpecificityStructureT-LymphocyteT-Lymphocyte EpitopesTestingTherapeuticToxic effectToxinTrastuzumabTumor AntigensUnited StatesXenograft ModelXenograft procedurebasebevacizumabcDNA Librarycancer cellcancer immunotherapycancer stem cellcancer therapycell killingchimeric antigen receptorcytotoxicefficacy testingglycosylationhuman monoclonal antibodiesimmunogenicityin vitro activityin vitro testingin vivokillingslymph nodesmalignant breast neoplasmmouse modelnovelpublic health relevanceresearch studyresponsescreeningsuccesstumortumorigenesis

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英文摘要
 DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer death in the United States, but the promise of therapies based on monoclonal antibodies (mAbs) has been unrealized due to the lack of known antibody targets specific for lung cancer cells. This research will address this need by characterizing three new lung cancer-specific mAbs that were cloned from patients with cancer and have shown cytotoxic activity in vitro when converted into antibody drug conjugates. We will convert them into immunotoxins and test them for and determine their specificity, safety and efficacy against lung cancer.
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Comprehensive functional assesment of the human antibody response to Enterovirus 71
Immunotoxins based on the IgG response to autologous antigens in cancer patients
Human Monoclonal Antibodies that Bind Botulinum Toxins
Human Monoclonal Antibodies that Bind Botulinum Toxins
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