Development and Validation of an HIV Risk Assessment Tool for African Women

为非洲妇女开发和验证艾滋病毒风险评估工具

• 批准号: 8984923
• 负责人: Jennifer Ellen Balkus
• 金额: $ 9.33万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8984923
• 关键词: AIDS prevention; Accounting; Africa; African; Assessment tool; Behavioral; Characteristics; Clinical; Clinical Trials; Counseling; Country; Couples; Data; Databases; Development; Enrollment; Epidemiology; Foundations; Future; Goals; HIV; HIV Infections; HIV prevention trial; HIV prevention trials network; HIV risk; Health; Health Policy; Health Professional; High Risk Woman; Human immunodeficiency virus test; Incidence; Individual; Intervention; Laboratories; Life; Medical; Methods; Microbicide Trials Network; Modeling; Outcome; Policies; Policy Maker; Population; Positioning Attribute; Prevention Research; Prevention strategy; Preventive Intervention; Program Development; Prophylactic treatment; Protocols documentation; Public Health; Reporting; Research; Research Design; Research Personnel; Resources; Risk; Risk Assessment; Risk Factors; Risk Reduction; Science; Services; Site; United States; Validation; Woman; Women' s Group; Work; clinical practice; community setting; cost; data management; experience; high risk; improved; member; men who have sex with men; method development; microbicide; novel; prevention service; programs; scale up; tool

 DESCRIPTION: Women account for more than half of all new HIV infections globally, with the greatest incidence occurring in African women. Several recently completed biomedical HIV prevention trials in women have reported high incidence rates, as great as 10% at some study sites, despite the provision of comprehensive HIV risk reduction services during the trial. Improving our understanding of predictors of HIV acquisition in African women is urgently needed in order to identify opportunities for intervention among sub-groups of women at greatest risk and inform the scale-up of targeted HIV prevention activities. Empiric HIV risk scores have recently been developed for several populations, including African HIV serodiscordant couples and men who have sex with men in the United States. These tools not only help to identity those at greatest risk of acquiring HIV, they are also being used to guide th implementation of novel HIV prevention activities in these populations. A similar tool has not been developed for African women at risk for HIV. The goal of this proposal is to utilize the accumulated, high-quality databases from completed large-scale HIV prevention trials in women, including VOICE (MTN-003), HPTN 035, MDP301, FEM-PrEP, and ASPIRE (MTN-020), to develop and validate an HIV risk assessment tool for women living in Africa that identifies those who are at greatest risk of acquiring HIV in the next year. The findings from this highly leveraged proposal could have a major impact in the field of HIV prevention science by providing health workers, policy makers and HIV prevention researchers with a tool to identify populations at greatest risk of acquiring HIV, allowing for the opportunity to provide targeted, intensive prevention services to these high-risk women.

 妇女占全球所有新感染艾滋病毒者的一半以上，非洲妇女的发病率最高。最近完成的几项妇女艾滋病毒生物医学预防试验报告了高发病率，在一些研究地点高达10%，尽管在试验期间提供了全面的艾滋病毒风险降低服务。迫切需要提高我们对非洲妇女感染艾滋病毒的预测因素的认识，以确定在风险最大的妇女亚群体中进行干预的机会，并为扩大有针对性的艾滋病毒预防活动提供信息。经验性的艾滋病毒风险评分最近已制定了几个人群，包括非洲艾滋病毒血清不一致的夫妇和男性在美国与男性发生性关系的男子。这些工具不仅有助于识别那些最有可能感染艾滋病毒的人，而且还用于指导在这些人群中实施新的艾滋病毒预防活动。尚未为有感染艾滋病毒风险的非洲妇女开发类似的工具。该提案的目标是利用已完成的大规模妇女艾滋病毒预防试验积累的高质量数据库，包括VOICE（MTN-003）、HPTN 035、MDP 301、FEM-PrEP和ASPIRE（MTN-020），为生活在非洲的妇女开发和验证艾滋病毒风险评估工具，以确定明年感染艾滋病毒风险最大的妇女。这一发现 这一具有高度杠杆作用的提案可以在艾滋病毒预防科学领域产生重大影响，为卫生工作者、决策者和艾滋病毒预防研究人员提供一种工具，以确定感染艾滋病毒风险最大的人群，从而有机会向这些高危妇女提供有针对性的密集预防服务。