Impact of Drug Use Treatment on HIV Risk Behaviors: An Integrative Data Analysis

吸毒治疗对艾滋病毒危险行为的影响：综合数据分析

• 批准号: 8838085
• 负责人: Jennifer L Brown
• 金额: $ 0.61万
• 依托单位: TEXAS TECH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838085
• 关键词: AIDS prevention; Accounting; Address; Age; Alcohol or Other Drugs use; Behavior; Behavioral; Characteristics; Clinical Trials Network; Coitus; Communities; Data; Data Analyses; Data Set; Development; Drug abuse; Drug usage; Effectiveness; Effectiveness of Interventions; Ethnic Origin; Future; Gender; Goals; HIV; HIV Infections; HIV risk; Health; Healthy People 2020; Heterogeneity; Individual; Infection; Intervention; Length; Meta-Analysis; Modality; National Institute of Drug Abuse; Needle Sharing; Participant; Pharmaceutical Preparations; Physiological; Prevalence; Prevention approach; Prevention strategy; Publishing; Race; Research; Research Design; Risk; Risk Behaviors; Risk Reduction; Sampling; Targeted Research; United States; Vulnerable Populations; base; behavior test; cognitive process; data sharing; effective therapy; evidence base; high risk sexual behavior; injection drug use; novel; prevent; sex; sex risk; sexual encounter; statistics; transmission process; treatment trial

DESCRIPTION (provided by applicant): The proposed study will examine the extent to which extant behavioral drug abuse treatments are effective as an HIV prevention strategy using an integrative data analysis (IDA) approach. IDA allows for analysis of multiple original data sets that have been pooled into one using harmonized variables. This research will pool data from behavioral drug abuse treatments conducted through the National Institute on Drug Abuse's (NIDA) Clinical Trials Network (CTN). Specifically, this research will: (1) create a pooled data se with harmonized variables and corresponding harmonized data codebook combining data from 15 individual NIDA CTN behavioral drug abuse treatment trials (N=6,896 unique participants); (2) evaluate the extent to which NIDA CTN behavioral drug abuse treatments reduce HIV transmission risk behaviors defined as injection drug use, needle sharing, and sexual risk behaviors (e.g., unprotected sexual intercourse, trading sex for drugs) using the pooled data set with harmonized variables; and (3) examine potential moderators of the effectiveness of NIDA CTN behavioral drug abuse treatments to reduce HIV transmission risk behaviors. Core moderating factors that will be examined are sampling characteristics (e.g., age, gender, race/ethnicity, baseline drug use behavior engagement) and study design features (e.g., inclusion of HIV risk reduction intervention content, intervention modality, intervention length). Results from the proposed research will provide requisite information to guide the development, adaptation, and dissemination of future interventions to reduce and prevent both drug abuse and HIV.

描述（由申请人提供）：拟议的研究将使用综合数据分析（IDA）方法检查现有行为药物滥用治疗作为HIV预防策略的有效程度。IDA允许对多个原始数据集进行分析，这些数据集使用统一的变量合并为一个数据集。这项研究将汇集通过国家药物滥用研究所（NIDA）临床试验网络（CTN）进行的行为药物滥用治疗的数据。具体而言，本研究将：（1）创建一个汇集的数据se与协调变量和相应的协调数据码本，结合15个单独的NIDA CTN行为药物滥用治疗试验的数据（N= 6，896名独立参与者）;（2）评估NIDA CTN行为药物滥用治疗减少HIV传播风险行为（定义为注射吸毒，共用针头，和性风险行为（例如，无保护性交，性交易毒品）使用统一变量的汇总数据集;（3）检查NIDA CTN行为药物滥用治疗减少HIV传播风险行为的有效性的潜在调节因素。将检查的核心调节因素是抽样特征（例如，年龄、性别、种族/民族、基线药物使用行为参与）和研究设计特征（例如，包括降低艾滋病毒风险干预内容、干预方式、干预长度）。拟议研究的结果将提供必要的信息，以指导未来干预措施的制定、调整和传播，从而减少和预防药物滥用和艾滋病毒。