Impact of Drug Use Treatment on HIV Risk Behaviors: An Integrative Data Analysis

吸毒治疗对艾滋病毒危险行为的影响：综合数据分析

• 批准号: 8838085
• 负责人: Jennifer L Brown
• 金额: $ 0.61万
• 依托单位: TEXAS TECH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8838085
• 关键词: AIDS prevention; Accounting; Address; Age; Alcohol or Other Drugs use; Behavior; Behavioral; Characteristics; Clinical Trials Network; Coitus; Communities; Data; Data Analyses; Data Set; Development; Drug abuse; Drug usage; Effectiveness; Effectiveness of Interventions; Ethnic Origin; Future; Gender; Goals; HIV; HIV Infections; HIV risk; Health; Healthy People 2020; Heterogeneity; Individual; Infection; Intervention; Length; Meta-Analysis; Modality; National Institute of Drug Abuse; Needle Sharing; Participant; Pharmaceutical Preparations; Physiological; Prevalence; Prevention approach; Prevention strategy; Publishing; Race; Research; Research Design; Risk; Risk Behaviors; Risk Reduction; Sampling; Targeted Research; United States; Vulnerable Populations; base; behavior test; cognitive process; data sharing; effective therapy; evidence base; high risk sexual behavior; injection drug use; novel; prevent; sex; sex risk; sexual encounter; statistics; transmission process; treatment trial

DESCRIPTION (provided by applicant): The proposed study will examine the extent to which extant behavioral drug abuse treatments are effective as an HIV prevention strategy using an integrative data analysis (IDA) approach. IDA allows for analysis of multiple original data sets that have been pooled into one using harmonized variables. This research will pool data from behavioral drug abuse treatments conducted through the National Institute on Drug Abuse's (NIDA) Clinical Trials Network (CTN). Specifically, this research will: (1) create a pooled data se with harmonized variables and corresponding harmonized data codebook combining data from 15 individual NIDA CTN behavioral drug abuse treatment trials (N=6,896 unique participants); (2) evaluate the extent to which NIDA CTN behavioral drug abuse treatments reduce HIV transmission risk behaviors defined as injection drug use, needle sharing, and sexual risk behaviors (e.g., unprotected sexual intercourse, trading sex for drugs) using the pooled data set with harmonized variables; and (3) examine potential moderators of the effectiveness of NIDA CTN behavioral drug abuse treatments to reduce HIV transmission risk behaviors. Core moderating factors that will be examined are sampling characteristics (e.g., age, gender, race/ethnicity, baseline drug use behavior engagement) and study design features (e.g., inclusion of HIV risk reduction intervention content, intervention modality, intervention length). Results from the proposed research will provide requisite information to guide the development, adaptation, and dissemination of future interventions to reduce and prevent both drug abuse and HIV.

描述（由申请人提供）：拟议的研究将研究使用综合数据分析（IDA）方法作为预防艾滋病毒策略的现存行为滥用治疗的程度。 IDA允许分析已使用统一变量汇总为一个原始数据集。这项研究将从美国国家药物滥用研究所（NIDA）临床试验网络（CTN）进行的行为药物滥用治疗中汇集数据。具体而言，这项研究将：（1）创建一个合并的数据SE，该数据SE具有统一变量和相应的统一数据代码书，结合了15个NIDA CTN行为滥用治疗试验的数据（n = 6,896个独特的参与者）； （2）评估NIDA CTN行为滥用治疗的程度减少了艾滋病毒传播的风险行为，其定义为注射药物使用，针头共享和性风险行为（例如，使用带有协调变量的汇总数据，使用汇总的数据使用均值的数据，对药物进行交易，对药物进行交易）； （3）检查NIDA CTN行为滥用治疗的有效性的潜在主持人，以减少HIV传播风险行为。将要检查的核心调节因素是抽样特征（例如，年龄，性别，种族/种族，基线药物使用行为参与）和研究设计特征（例如，纳入HIV风险降低干预措施，干预方式，干预长度）。拟议研究的结果将提供必要的信息，以指导未来干预措施的发展，适应和传播，以减少和预防药物滥用和艾滋病毒。