Shared Resource: Biobanking and Correlative Sciences

共享资源：生物样本库和相关科学

• 批准号: 8997277
• 负责人: Julie Lynn Boerner
• 金额: $ 12万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8997277
• 关键词: African American; American; Animals; Arabs; Area; Back; Biological Assay; Biometry; Biopsy; Biostatistics Core; Blood specimen; Cancer Center Support Grant; Catchment Area; Cell Count; Cells; Clinical; Clinical Research; Clinical Trials; Clinical trial protocol document; Collaborations; Collection; Databases; Disease; Emergency Situation; Ensure; Equipment; Formalin; Freezing; Fresh Tissue; Funding; Genomics; Goals; Guidelines; Histology; Human; Informed Consent; Institutional Review Boards; Laboratories; Left; Location; Microtome - medical device; Minority; Monitor; Neoplasm Circulating Cells; Paraffin Embedding; Pathologist; Pathology; Pathology Report; Patients; Peer Review; Pharmacodynamics; Pharmacology; Population; Population Heterogeneity; Population Sciences; Proteomics; Publications; Research; Research Activity; Research Personnel; Resource Sharing; Sampling; Science; Scientist; Secure; Services; Site; Slide; Specimen; Staining method; Stains; System; Temperature; Tissue Fixation; Tissue Microarray; Tissues; Tumor Tissue; Whole Blood; biobank; cryostat; member; pre-clinical; preclinical study; tumor

PROJECT SUMMARY/ ABSTRACT The purpose of the Biobanking and Correlative Sciences (BCS) Core is to enhance the peer reviewed, funded research activities of KCI members whose research requires IRB-approved access to patient tissue for preclinical and clinical studies and to support clinical trials by managing tissue specimens and providing circulating tumor cell counting. The BCS Core is grouped in the Cross Disciplinary Research Core Cluster which, in addition to the BCS Core, includes the Biostatistics, Genomics, and Pharmacology Cores. The BCS Core provides KCI investigators with high quality, well-annotated tumor tissue specimens for pre- clinical studies and coordinates requests for tumor tissues with the Genomics, Pharmacology and Proteomics Cores. Disease site-specific pathologists review tissues for selection of appropriate samples. This ensures there is appropriate and adequate tissue in the amounts and numbers needed for a given study to provide biologically meaningful results as determined by the Biostatistics Core. Institutional funds support the contributions of the pathologists. Fresh frozen specimens in the KCI Biobank are stored in eight -80⁰C freezers, which are temperature monitored and have back up emergency power. All specimens are barcoded and stored in cryosafe containers. Secured cabinets store formalin-fixed paraffin embedded (FFPE) specimens and any prepared slides from the biospecimens. Each biospecimen is logged into the KCI database, OnCore®, with its precise location, associated informed consent, pathology report, and amount of available tissue. Histology services are supported by a tissue processor, a tissue embedder, microtomes, a cryostat, and other ancillary histology equipment. For pharmacodynamic assays, the core contains a Janssen Cell Search Circulating Tumor Cell system, which enables investigators to enumerate and/or isolate circulating tumor cells. The services provided by the Biobanking and Correlative Sciences Core have contributed to 21 peer- reviewed publications during the current review period.

项目总结/摘要 生物库和相关科学（BCS）核心的目的是加强同行评审， 资助KCI成员的研究活动，其研究需要IRB批准的患者组织获取， 临床前和临床研究，并通过管理组织标本和提供 循环肿瘤细胞计数。BCS核心被分组在跨学科研究核心集群中 其中，除了BCS核心，还包括生物统计学，基因组学和药理学核心。 BCS Core为KCI研究者提供了高质量、注释良好的肿瘤组织标本， 临床研究，并与基因组学、药理学和 蛋白质组学核心。疾病部位特异性病理学家审查组织以选择适当的样本。 这确保了给定研究所需的量和数量的适当和足够的组织 提供生物统计学核心确定的具有生物学意义的结果。机构资金支持 病理学家的贡献。 KCI生物库中的新鲜冷冻标本储存在8个-80 ° C的冷冻箱中， 并有备用应急电源。所有标本都有条形码并储存在冷冻柜中 容器.安全柜储存福尔马林固定石蜡包埋（FFPE）标本和任何制备的 生物标本的切片每个生物样本都记录在KCI数据库OnCore®中， 位置、相关知情同意书、病理报告和可用组织量。组织学服务 由组织处理器、组织包埋器、切片机、低温恒温器和其他辅助组织学支持 设备.对于药效学试验，核心包含Janssen Cell Search循环肿瘤细胞 该系统使研究人员能够计数和/或分离循环肿瘤细胞。 生物库和相关科学核心提供的服务为21个同行提供了帮助， 在本审查期内审查出版物。