IGF::OT::IGF TASK ORDER 1: ONE-DOSE TRIAL SETUP, ENROLLMENT AND IMMUNIZATION

本合同的目标是支持一项新的试验，旨在评估1剂与2剂HPV疫苗的非劣效性，并进一步延长对NCI正在进行的哥斯达黎加疫苗试验（CVT）中的妇女的随访（该试验最初对妇女进行了10年随访，现在将在一部分参与者中将随访延长至15年）。在接受一剂、两剂和三剂HPV16/18疫苗的妇女中，CVT在四年中显示出相似的HPV疫苗效力，并且在CVT迄今累积的七年随访中观察到稳定的抗体反应。对这些发现采取后续行动，并进一步记录较少剂量所提供的保护，可能会带来重大的全球公共卫生突破。

This objective of this contract is to support a new trial aimed at evaluating the non-inferiority of 1 versus 2 doses of the HPV vaccines and an additional extension to the follow-up of women in NCI’s ongoing Costa Rica Vaccine Trial (CVT) (which initially followed women for 10 years and will now extend that follow up out to 15 years among a subset of participants). CVT showed similar HPV vaccine efficacy over four years among women who received one, two and three doses of the HPV16/18 vaccine, and stable antibody responses have been observed throughout the seven years of follow-up accrued to date in CVT. Following up on these discoveries and further documenting the protection afforded by fewer doses could result in a monumental, global public health breakthrough.