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Structure-Function Studies Of DNA Replication Fidelity

Structure-Function Studies Of DNA Replication Fidelity
DNA 复制保真度的结构功能研究
批准号：
9550070
负责人：
THOMAS A KUNKEL
金额：
$218.16万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9550070
关键词：
Biochemical GeneticsCell DeathCell SurvivalCrystallizationDNA Double Strand BreakDNA Polymerase IIDNA RepairDNA StructureDNA biosynthesisDNA polymerase muDNA-Directed DNA PolymeraseGenetic studyGenome StabilityGenomic InstabilityGoalsHealthHumanIonsMusMutagenesisNuclearProcessPropertyPublishingRibonucleotidesRoentgen RaysStressStructureSurgical incisionsTopoisomeraseYeastsdivalent metalin vivoreplicase

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英文摘要
This year, our group published nine scientific articles related to DNA replication fidelity. We showed that ribonucleotides incorporated during eukaryotic nuclear DNA replication are subject to formation of double strand DNA breaks that result in genome instability. These breaks are due to topoisomerase 1 incision of ribonucleotides incorporated by DNA polymerase epsilon, the primarily leading strand replicase. We collaborated with others to describe the X ray crystal group of DNA polymerase mu bound to a ribonucleotide, and to show that a third divalent metal ion is involved in DNA synthesis by DNA polymerase mu. We also published six review articles.
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DNA REPLICATION FIDELITY
STUDIES OF DNA MISMATCH REPAIR
Structure-Function Studies Of DNA Replication Fidelity
DNA Replication Fidelity
国内基金
海外基金
炎性反应中巨噬细胞激活诱导死亡（activation-induced cell death,AICD)的机理研究
  • 批准号：
    30330260
  • 项目类别：
    重点项目
  • 资助金额：
    105.0万元
  • 批准年份：
    2003
  • 负责人：
    顾军
  • 依托单位：
    北京大学