权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The Sleep Experience of Mothers with Hospitalized Preterm Infants and Subsequent Breast Milk Profiles

住院早产儿母亲的睡眠经历以及随后的母乳情况

基本信息

批准号：
9393529
负责人：
Kelley Baumgartel
金额：
$ 5.71万
依托单位：
MAGEE-WOMEN'S RES INST AND FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9393529
关键词：
Academy American Anxiety Bacterial DNA Biological Breast Feeding Care given by nurses Characteristics Circadian Rhythms Clinical Communication Complication Critically ill children Data Data Collection Development Environment Exposure to Future Health Healthcare Hospitals Host Defense Human Milk Hygiene Infant Intervention Knowledge Lead Lighting Link Measurement Measures Mental Depression Methods Milk Molecular Mothers Necrotizing Enterocolitis Neonatal Neonatal Intensive Care Neonatal Intensive Care Units Neonatal Nursing Nurses Observational Study Outcome Pattern Pittsburgh Sleep Quality Index Population Post-Traumatic Stress Disorders Postpartum Period Premature Birth Premature Infant Preparation Pump Recommendation Reporting Ribosomal RNA Risk Sampling Science Sleep Time Translating Variant Woman Work Wrist actigraphy base breast pump circadian pacemaker commensal microbes cost design donor milk experience fortification gastrointestinal gut microbiota high risk improved inter-individual variation microbiota milk expression milk production milk volume neonatal outcome novel pasteurization premature prospective psychologic rRNA Genes sleep regulation virtual

项目摘要

Project Summary / Abstract Background: The postpartum experience of preterm mothers is unlike the biological norm, and their sleep experience is poorly understood. Preterm mothers are physically separated from their infants, and few report waking through the night to pump breast milk, which may contribute to breast milk insufficiency. Breast milk insufficiency is common, and many preterm mothers cannot pump enough milk to meet their infant's needs. Despite this common obstacle, and the benefits of sleep to overall health, the relationship between objective maternal sleep measures and subsequent milk volume has never been explored. When a preterm mother experiences milk insufficiency, donor milk is prescribed; however, pasteurized donor milk contains no commensal bacteria, which are associated with improved neonatal outcomes. Milk microbiota profiles are highly variable between women, and some profiles are more protective. Factors that influence milk microbiota are poorly understood, though emerging evidence suggests a diurnal influence. Subject Population: Breastfeeding mothers with hospitalized preterm infants. Design: Maternal sleep characteristics and milk profiles (microbiota and volume) will be examined in this longitudinal, prospective, observational study. Methods: Subjects will wear an Actiwatch 2 (Philips Respironics) and complete daily sleep and pumping logs before discharge from the hospital. Once breast milk has come in and for one week, two daily breast milk samples (one daytime, one nighttime) will be collected. Bacterial DNA will be extracted from breast milk samples, 16S rRNA PCR amplification will be performed, and amplicons will be sequenced using Illumina MiSeq. Analysis: Group-based trajectory analysis will be applied to identify distinct sleep and milk profile patterns. Relevance to NINR: Neonatal Intensive Care nurses are directly involved in both: 1) the support of new mothers (including sleep hygiene), and 2) breast milk administration (tracking, storage, measurement, fortification, and preparation). This study will inform future strategies related to sleep support and personalized breast milk for preterm infants.

项目总结/摘要背景：早产儿母亲的产后经历与生物学规范不同，人们对经验知之甚少。早产母亲与婴儿身体分离，很少有人报告整夜醒来吸母乳，这可能导致母乳不足。母乳母乳不足是很常见的，许多早产母亲不能泵出足够的母乳来满足婴儿的需要。尽管有这一常见的障碍，以及睡眠对整体健康的好处，但客观的睡眠与睡眠之间的关系，母亲的睡眠测量和随后的奶量从未被探索过。当一个早产的母亲如果出现乳汁不足，则应开具捐赠乳汁的处方;然而，经巴氏消毒的捐赠乳汁不含肠道细菌，与改善新生儿结局相关。牛奶微生物群概况是女性之间的差异很大，有些特征更具保护性。影响牛奶微生物群的因素尽管新出现的证据表明存在昼夜影响，但人们对此知之甚少。受试者人群：母乳喂养早产儿住院的母亲。设计：产妇睡眠特点与乳汁在这项纵向、前瞻性、观察性研究中，将对微生物群和体积进行检查。方法：受试者将佩戴Actiwatch 2（Philips Respironics）并完成每日睡眠和泵送日志在出院之前。一旦母乳进入，一周内，每天两次母乳将采集样本（一天，一晚）。将从母乳中提取细菌DNA 样本，将进行16 S rRNA PCR扩增，并使用Illumina对扩增子进行测序 MiSeq分析：将应用基于组的轨迹分析来识别不同的睡眠和乳汁特征模式.与NINR的相关性：新生儿重症监护护士直接参与：1）新妈妈（包括睡眠卫生），和2）母乳给药（跟踪，储存，测量，强化和制备）。这项研究将为未来的睡眠支持和个性化策略提供信息。早产儿的母乳。