Effect of low-intensity versus moderate-intensity endurance exercise on physical functioning among breast cancer survivors: a randomized controlled trial

低强度与中等强度耐力运动对乳腺癌幸存者身体功能的影响：一项随机对照试验

• 批准号: 9242649
• 负责人: Ana L Mulero-Portela
• 金额: $ 11.25万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-11 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9242649
• 关键词: Address; Adherence; Adjuvant Therapy; Age; Age-Years; American Cancer Society; Attitude; Behavior; Behavior Control; Behavioral; Blinded; Breast Cancer Patient; Breast Cancer Rehabilitation; Breast Cancer Treatment; Breast Cancer survivor; Cancer Patient; Cancer Survivor; Caring; Chronic; Chronic Disease; Clinical; Correlation Studies; Data; Diagnosis; Dose; Early Diagnosis; Early treatment; Elderly; Evaluation; Exercise; Experimental Designs; Face; Female Breast Carcinoma; Future; Guidelines; Hair; Health Benefit; Health Professional; Hispanics; Home environment; Intervention; Literature; Long-Term Effects; Malignant Neoplasms; Measures; Mediating; Mediator of activation protein; Mental Health; Methodology; Minority; Mission; Not Hispanic or Latino; Operative Surgical Procedures; Outcome; Outcome Measure; Participant; Patients; Physical Function; Planning Theory; Population; Puerto Rico; Randomized; Randomized Controlled Trials; Recommendation; Research; Sampling; Societies; Survivors; Testing; Time; Treatment outcome; United States; United States National Institutes of Health; Woman; arm; base; behavior change; cancer diagnosis; cancer therapy; design; endurance exercise; exercise adherence; exercise intensity; exercise intervention; exercise program; follow-up; health disparity; health related quality of life; high risk; improved; intervention effect; malignant breast neoplasm; middle age; physical therapist; prevent; primary outcome; public health relevance; relative effectiveness; survivorship; theories

 DESCRIPTION (provided by applicant): Improvements in early diagnosis and treatment for breast cancer in women have resulted in increased survivorship. An unintended consequence of increased survival, however, is that more women are living with the negative sequelae associated with cancer treatment, including decreased physical function. Exercise has been beneficial in arresting these sequelae, but adherence to exercise guidelines continues to be a challenge. As most breast cancer survivors are middle-aged and older, an alternative to enhance exercise engagement and adherence might be providing a low intensity exercise program. The overall purpose of this study is to assess the impact of a low intensity versus moderate intensity endurance exercise program on physical functioning on breast cancer survivors. It is hypothesized that participants of the low intensity exercise program will demonstrate similar physical functioning as participants in the moderate intensity exercise program. The Theory of Planned Behavior will serve as framework for the intervention. A convenience sample of 142 women, residents of Puerto Rico, age 50 or older, with a diagnosis of unilateral breast cancer, stage 0 thru II, who have received surgical treatment for breast cancer, with or without adjuvant therapy, will be randomly assigned to a low intensity or moderate intensity endurance intervention. Both interventions will be home-based, have a duration of 6 months, and be provided by physical therapists. An evaluator blinded to group assignment will assess participants at baseline and at completion of the intervention. Primary outcome measures will consist of physical functioning, and health-related quality of life.

 描述（由申请人提供）：女性乳腺癌早期诊断和治疗的改善提高了生存率。然而，生存率提高的一个意想不到的后果是，更多的妇女生活在与癌症治疗相关的负面后遗症中，包括身体功能下降。锻炼对预防这些后遗症是有益的，但坚持锻炼指南仍然是一个挑战。由于大多数乳腺癌幸存者都是中年和老年人，提高运动参与度和坚持性的另一种选择可能是提供低强度运动计划。本研究的总体目的是评估低强度与中等强度耐力运动计划对乳腺癌幸存者身体功能的影响。假设低强度锻炼计划的参与者将表现出与中等强度锻炼计划的参与者相似的身体功能。计划行为理论将作为干预的框架。142名女性（波多黎各居民，年龄≥ 50岁，诊断为单侧乳腺癌，0-II期，接受过乳腺癌手术治疗，伴或不伴辅助治疗）的便利样本将被随机分配至低强度或中等强度耐力干预组。这两种干预措施都是以家庭为基础的，为期6个月，由物理治疗师提供。对分组设盲的评价者将在基线和干预完成时评估受试者。主要结局指标将包括身体功能和健康相关的生活质量。