Mineralomics: Designing mineral based therapeutics to control and direct cell function

总结 提出了一组实验来开发一种新的基于矿物的纳米颗粒技术，用于调节 在缺乏生长因子的情况下的细胞活性，用于再生疗法。目前的治疗方法 调节细胞反应包括递送大量超生理剂量的生长因子， 导致一系列并发症，包括不受控制的组织形成、炎症和肿瘤发生。 这些不利地限制了生长因子在再生医学领域中作为治疗剂的使用。 在这个新的创新者奖，我建议开发新的矿物基纳米粒子，以调节和指导 人类干细胞在缺乏生长因子的情况下的分化。我们期望， 有效的无生长因子疗法可以通过利用我们的 了解矿物质诱导的分子信号。这个研究建议特别好 适合这种独特的资助机制，因为它提出了创新，高风险和高回报的研究 在生物工程和干细胞的界面上，这将对修复和再生产生重大影响。 受损组织我们建议将高通量计算基因组学、干细胞的原理联合收割机结合起来 生物学、材料科学、微制造和再生医学，以设计基于 矿物质诱导细胞信号传导的新出现但未探索的概念。我们期望， 全面了解矿物使用所调节的分子途径将从根本上 改变目前以生长因子为基础的修复和再生受损组织的方法。 !

SUMMARY A set of experiments is proposed to develop a new mineral-based nanoparticle technology for modulating the cellular activity in absence of growth factors for regenerative therapies. Current therapeutic approaches to regulate cellular responses include delivery of a multitude of supraphysiological doses of growth factors that results in a range of complications, including uncontrolled tissue formation, inflammation, and tumorogenesis. These adversely limit the usage of growth factors as a therapeutic agent in the field of regenerative medicine. In this New Innovator Award, I propose to develop new mineral-based nanoparticles to regulate and direct the differentiation of human stem cells in the absence of growth factors. It is our expectation that adequate and efficacious grow-factor free therapeutics can be designed for regenerative medicine by leveraging our knowledge about the molecular signaling induced by minerals. This research proposal is particularly well suited for this unique funding mechanism because it proposes innovative, high-risk, and high-reward research at the interface of bioengineering and stem cells that would have a major impact on repair and regeneration of damaged tissue. We propose to combine principles of high throughput computational genomics, stem cell biology, materials science, microfabrication, and regenerative medicine to design novel strategies based on newly emerging but unexplored concepts of mineral-induces cellular signaling. It is our expectation that a comprehensive understanding of the molecular pathways regulated by the usage of minerals will radically alter the current growth-factor based approach to repair and regenerate damage tissue. !