2017 Cell Biology of Metals Gordon Research Conference and Gordon Research Seminar

项目说明(摘要/摘要) 戈登研究会议(GRC)系列“金属细胞生物学”提供了一个真正的 年新兴金属领域科学交流、演讲和讨论的杰出论坛 生物学，重点研究蛋白质、细胞和系统中金属的获取、分布、传感和利用 从细菌到人类。这一GRC系列于2005年启动，在下一个周期中立即 超额认购，说明这次会议填补了探索 金属在蛋白质、细胞器和整个生物体中的利用。这次会议现在已经成为一种 是该领域的基石，在解决广泛的研究问题方面是独一无二的，例如金属辅因子是如何 金属离子如何在新陈代谢和传染病中发挥作用。金属GRC的细胞生物学 每两年举行一次，一直吸引着140多人参加。戈登研究 系列会议以其会议的高质量、尖端性质而享誉国际， 展示未发表的工作；拟议的2017年会议的议程努力保持这一高水平 标准的。 2017年金属细胞生物学GRC将于7月23日至28日在佛蒙特州西多佛市的雪山举行。这 应用程序描述了初步计划，该计划围绕主题为“机制来自 微生物对人类的影响“。会议主题包括金属在酶中的作用、金属酶结构、金属 动态平衡，金属感应和动力学，金属蛋白生物发生和信号，寄主-病原体中的金属 生理学和疾病中的相互作用和金属。会议将由主旨演讲组成 演讲、研究和海报演讲、海报讨论和非正式的科学讨论。这次会议 将汇聚一批杰出而多样的分子和结构生物学家、生物化学家、 遗传学家、细胞生物学家、生理学家和临床医生就新的发现、想法和 金属细胞生物学基础和应用研究方向。鉴于……数量的增加 代谢和传染病与细胞金属动态平衡的变化有关，这次会议填补了一个关键的 研究这些疾病的潜在机制的利基(S)和集思广益的方法 新的诊断学、预测学和治疗学。

Project Description (Summary/Abstract) The Gordon Research Conference (GRC) series on the “The Cell Biology of Metals” provides a truly outstanding forum for scientific exchanges, presentations and discussions in the emerging field of metals in biology, focusing on the acquisition, distribution, sensing and utilization of metals in proteins, cells and systems from bacteria to humans. This GRC series was initiated in 2005 and in the next cycle was immediately oversubscribed, illustrating that the meeting filled an important niche exploring the molecular mechanisms of metal utilization in proteins, organelles, and whole organisms. This conference has now become a cornerstone of the field and is unique in attacking broad research questions such as how metal cofactors are assembled to how metal ions play roles in metabolic and infectious diseases. The Cell Biology of Metals GRC is held every two years and has consistently attracted more than 140 attendees. The Gordon Research Conference series is internationally renowned for the high-quality, cutting edge nature of its meetings, showcasing unpublished work; the program of the proposed 2017 conference strives to maintain this high standard. The 2017 Cell Biology of Metals GRC will be held on July 23 – 28 at Mount Snow in West Dover, VT. This application describes the preliminary program, which is organized around the theme of “Mechanisms from Microbes to Humans”. Session topics include metals in enzyme function, metalloenzyme strucutres, metal homeostasis, metal sensing and dynamics, metalloprotein biogenesis and signaling, metals in host-pathogen interactions and metals in physiology and disease. The conference will be comprised of keynote presentations, research and poster talks, poster discussions, and informal scientific discussions. This meeting will bring together an outstanding and diverse cadre of molecular and structural biologists, biochemists, geneticists, cell biologists, physiologists and clinicians to interact and brainstorm on new discoveries, ideas and directions in basic and applied research on the cell biology of metals. Given the increase in the number of metabolic and infectious diseases linked to changes in cellular metal homeostasis, this meeting fills a critical niche for investigating the underlying mechanism(s) of these disorders and for brainstorming approaches for novel diagnostics, prognostics, and therapeutics.