2nd International Conference of the Trisomy 21 Research Society

摘要 唐氏综合征(DS)是由人类21号染色体三体引起的。该综合征的特点是 由认知缺陷引起的大脑宏观和微观层面的特定结构异常 和智力残疾，以及中年患阿尔茨海默氏症的风险大大增加。近年来， 许多新的治疗策略在DS的细胞和动物模型中都显示出了希望，其中两个 目前正在进行重大临床试验。当今该领域面临的一个主要挑战是翻译基础科学 发现了治疗DS患者的有效方法。在中国取得的快速进展 过去几年需要科学家和在该领域工作的临床医生之间进行有效的沟通。在……里面 在这方面，以前的DS讲习班、21三体研究会第一次国际会议 (T21RS)和最近的Keystone研讨会对促进科学交流起到了重要作用， 最大限度地利用资源，并在基础、转化和临床领域定义最有前途的研究 级别。这项申请要求专门为美国青少年的旅行费用提供资金。 调查人员、博士后研究员和研究生出席T21RS第二次会议。我们 预计全球约有250名参与者，包括已建立的DS和非DS 研究人员的研究直接或间接地为DS认知、神经病理学、 翻译机会和临床试验。会议将于#年6月4日至6月7日在芝加哥举行 2017年，西北大学范伯格医学院范堡馆会议中心 (SOM)。Feinberg SOM成立于1859年，处于研究计划、一流临床护理和 全球展望。它代表了会议的理想环境。范伯格展馆位于 位于芝加哥市中心，并配备了最先进的视听能力。海报会议将 将在相邻的中庭部分举行。我们期待这次会议将导致富有成果的讨论和 新的合作对定义DS研究的未来至关重要。

Abstract Down syndrome (DS) is caused by trisomy of chromosome 21 in humans. The syndrome is characterized by specific structural abnormalities in the brain at the macroscopic and microscopic level, by cognitive deficits and intellectual disability and by greatly increased risk of Alzheimer's dementia by middle age. In recent years, a number of novel therapeutic strategies have shown promise in both cellular and animal models of DS, two of which are currently in major clinical trials. A major challenge for the field today is translating basic science discoveries into effective treatments for people with DS. The rapid pace of progress that has taken place in the last few years demands effective communication between scientists and clinicians working in the field. In this regard, previous DS Workshops, the 1st International Conference of the Trisomy 21 Research Society (T21RS) and a recent Keystone symposium have been instrumental in promoting scientific exchanges, maximizing resource use and defining the most promising research at the basic, translational and clinical levels. This application requests funding exclusively for travel expenses of American-based junior investigators, postdoctoral fellows and graduate students to attend the second meeting of the T21RS. We expect approximately 250 participants form around the world including established DS and non-DS investigators whose research directly or indirectly informs critical aspects of DS cognition, neuropathology, translational opportunities, and clinical trials. The meeting will take place in Chicago from June 4 to June 7 of 2017, at the Feinberg Pavilion Conference Center, Northwestern University Feinberg School of Medicine (SOM). Founded in 1859, the Feinberg SOM is at the forefront of research initiatives, superb clinical care and global outlook. It represents an ideal environment for the conference. The Feinberg Pavilion is located in the heart of the city of Chicago and is equipped with state-of-the-art audiovisual capabilities. Poster sessions will be hosted in the adjacent Atrium section. We anticipate that this conference will lead to fruitful discussions and novel collaborations that will be essential to define the future of DS research.