2nd International Conference of the Trisomy 21 Research Society

21三体研究会第二届国际会议

• 批准号: 9261363
• 负责人: JORGE A BUSCIGLIO
• 金额: $ 1.8万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9261363
• 关键词: Affect; Alzheimer' s Disease; American; Animal Model; Applied Research; Area; Basic Science; Biological Markers; Biological Models; Brain; Cell model; Chicago; Chromosomes, Human, Pair 21; Cities; Clinical; Clinical Research; Clinical Trials; Cognition; Cognitive; Cognitive deficits; Collaborations; Communication; Complex; Dementia; Development; Down Syndrome; Educational workshop; Environment; Fostering; Foundations; Funding; Future; Gene Dosage; Genotype; Goals; Heart; Heart Atrium; Human; Human Chromosomes; In Vitro; Intellectual functioning disability; International; Knowledge; Laboratories; Lead; Learning; Melissa; Memory impairment; Microscopic; Molecular; National Institute of Child Health and Human Development; Paris, France; Participant; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phenotype; Postdoctoral Fellow; Predisposition; Quality of life; Request for Applications; Research; Research Personnel; Resources; Risk; Scientist; Societies; Structural defect; Syndrome; Therapeutic Intervention; Translating; Translational Research; Travel; Trisomy; Universities; Work; abstracting; base; brain abnormalities; clinical care; clinical practice; cognitive process; drug development; effective therapy; gene function; gene product; graduate student; improved; induced pluripotent stem cell; innovation; interest; medical schools; meetings; middle age; neuropathology; novel; novel marker; novel therapeutics; posters; programs; scientific organization; success; symposium

Abstract Down syndrome (DS) is caused by trisomy of chromosome 21 in humans. The syndrome is characterized by specific structural abnormalities in the brain at the macroscopic and microscopic level, by cognitive deficits and intellectual disability and by greatly increased risk of Alzheimer's dementia by middle age. In recent years, a number of novel therapeutic strategies have shown promise in both cellular and animal models of DS, two of which are currently in major clinical trials. A major challenge for the field today is translating basic science discoveries into effective treatments for people with DS. The rapid pace of progress that has taken place in the last few years demands effective communication between scientists and clinicians working in the field. In this regard, previous DS Workshops, the 1st International Conference of the Trisomy 21 Research Society (T21RS) and a recent Keystone symposium have been instrumental in promoting scientific exchanges, maximizing resource use and defining the most promising research at the basic, translational and clinical levels. This application requests funding exclusively for travel expenses of American-based junior investigators, postdoctoral fellows and graduate students to attend the second meeting of the T21RS. We expect approximately 250 participants form around the world including established DS and non-DS investigators whose research directly or indirectly informs critical aspects of DS cognition, neuropathology, translational opportunities, and clinical trials. The meeting will take place in Chicago from June 4 to June 7 of 2017, at the Feinberg Pavilion Conference Center, Northwestern University Feinberg School of Medicine (SOM). Founded in 1859, the Feinberg SOM is at the forefront of research initiatives, superb clinical care and global outlook. It represents an ideal environment for the conference. The Feinberg Pavilion is located in the heart of the city of Chicago and is equipped with state-of-the-art audiovisual capabilities. Poster sessions will be hosted in the adjacent Atrium section. We anticipate that this conference will lead to fruitful discussions and novel collaborations that will be essential to define the future of DS research.

摘要 唐氏综合征（Down syndrome，DS）是由人类21号染色体三体性引起的一种疾病。该综合征的特点是 在宏观和微观层面上，通过认知缺陷导致大脑中的特定结构异常 和智力残疾，并大大增加了中年时患阿尔茨海默氏痴呆症的风险。近年来， 许多新的治疗策略已经在DS的细胞和动物模型中显示出希望， 目前正在进行临床试验。当今该领域的一个主要挑战是将基础科学翻译成 为DS患者提供有效治疗的新发现。在这方面取得的迅速进展， 过去几年要求在该领域工作的科学家和临床医生之间进行有效的沟通。在 在这方面，以前的DS研讨会，21三体研究学会第一届国际会议 （T21RS）和最近的Keystone研讨会有助于促进科学交流， 最大限度地利用资源，并确定最有前途的基础研究，转化和临床 程度.此申请要求资金专门用于旅行费用的美国为基础的初级 研究人员、博士后研究员和研究生参加T21RS第二次会议。我们 预计全球约有250名参与者，包括已建立的DS和非DS 研究者的研究直接或间接地告知DS认知，神经病理学， 转化机会和临床试验。会议将于2010年6月4日至6月7日在芝加哥举行。 2017年，在Feinberg Pavilion会议中心，西北大学Feinberg医学院 （SOM）。Feinberg SOM成立于1859年，处于研究计划、一流临床护理和 全球展望。它为会议提供了理想的环境。范伯格馆位于 位于芝加哥市中心，配备了最先进的视听功能。海报会议将 在相邻的中庭部分。我们期望这次会议将导致富有成果的讨论， 新的合作，将是必不可少的定义未来的DS研究。

项目成果

Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society.

为治疗铺平道路：21 三体研究学会第二届国际会议。

• DOI: 10.1159/000494231
• 发表时间: 2019
• 期刊: Molecular syndromology
• 影响因子: 1.1
• 作者: Reeves,RogerH;Delabar,Jean;Potier,Marie-Claude;Bhattacharyya,Anita;Head,Elizabeth;Lemere,Cynthia;Dekker,AlainD;DeDeyn,Peter;Caviedes,Pablo;Dierssen,Mara;Busciglio,Jorge
• 通讯作者: Busciglio,Jorge