Biomedical Informatics and Statistics Core

生物医学信息学和统计核心

• 批准号: 9404837
• 负责人: Lei Liu
• 金额: $ 17.04万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9404837
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Adult; Africa; American; Area; Biological Markers; Biometry; Cervical; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Communicable Diseases; Communication; Communities; Consultations; Country; Coupled; Data; Data Collection; Data Quality; Databases; Development Plans; Diagnostic; Educational Curriculum; Emergency Situation; Epigenetic Process; Foundations; Funding; Future; Genetic Research; Genomics; Goals; Grant; HIV; Health; Healthcare; Hepatitis B; Hepatitis C; Human Papillomavirus; Income; Informatics; Inpatients; Institutes; Institution; International; International AIDS; Leadership; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical; Medical Education; Medical Research; Mentors; Modernization; Molecular Epidemiology; Needs Assessment; Nigeria; Nigerian; Outcome; Outpatients; Pathology; Patients; Positioning Attribute; Prevention; Prevention Research; Primary carcinoma of the liver cells; Protocols documentation; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Proposals; Research Training; Resources; Sampling; Services; Statistical Data Interpretation; Surveys; System; Time; Training Activity; Training Programs; Training Support; United States National Institutes of Health; Universities; Viral hepatitis; Virus; Virus Diseases; anticancer research; biomedical informatics; cancer care; cancer genetics; career; community organizations; data integration; data management; data sharing; disorder prevention; electronic data; epidemiology study; epigenomics; global health; improved; infrastructure development; inter-institutional; interdisciplinary approach; interest; international center; medical schools; neoplasm registry; operation; programs; quality assurance; repository; response; statistics

Project Summary We propose to establish a Consortium to study “Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria.” Our research focus and core services development plan has been prioritized by our Nigerian partners at University of Jos (UniJos), Plateau State, Nigeria located in the center of the country and University of Lagos (UniLag), Lagos State in the densely populated southwest. Our focus on the epigenetics of HIV-associated hepatocellular carcinoma (HCC) and cervical cancer is justified by our extensive collaborative research history in viral diseases including HIV, human papilloma virus, hepatitis B and C viruses. Northwestern University and Mayo Medical School will serve as the high-income American partner institutions which is justified by the long history of research and research training collaboration with the Nigerian institutions coupled with its expertise in global health and ample complementary resources. The specific aims of the Biomedical Informatics and Statistics Core (BISC) are: 1. enhance the existing clinical systems (HIV clinic electronic databases and cancer registries) to develop high-quality electronic clinical data collection on HIV-associated cancers across outpatient and inpatient systems at UniJos and UniLag, 2. develop a collaborative biomedical informatics and statistics team focused on providing core services for HIV-associated cancer genetics research in Nigeria, and 3. provide oversight and support for the informatics and statistical needs of Projects 1 (HCC) and 2 (cervical) proposed under this U54. Under this BISC, electronic data collection and management capabilities will be coordinated into a single Cancer Research Informatics System (CRIS). CRIS will include the following aspects: (1) data collection, (2) survey distribution for needs assessments and community engagement, (3) communication and BISC coordination, (4) financial/grants management, (5) data management and quality assurance, (6) linkage of clinical data and research biospecimen repository samples, (7) tracking/compliance of research proposals, and (8) tracking and outcomes of BISC services. The following BISC services will also be developed: centralized data integration and management, computational facilities and biostatistical consultations. The overall goal of the BISC will be to support and facilitate research proposed in Projects 1 (HCC) and 2 (cervical), provide facilities for training activities under the Career Enhancement Core (CEC), coordination of research services with the Pathology and Genomics Core (PGC), build infrastructure and research management with the Administrative Core (AC).

项目摘要 我们建议成立一个联盟来研究“尼日利亚艾滋病毒相关癌症的表观基因组生物标记物”。 我们的研究重点和核心服务发展计划已被我们的尼日利亚合作伙伴优先考虑， 乔斯大学(UniJos)，位于尼日利亚中部的高原州立大学和拉各斯大学 位于人口稠密的西南部的拉各斯州(UNILAG)。我们对HIV相关表观遗传学的关注 我们广泛的合作研究历史证明了肝细胞癌和宫颈癌是合理的 在包括艾滋病毒、人乳头瘤病毒、乙型和丙型肝炎病毒在内的病毒性疾病中。西北大学和 梅奥医学院将作为高收入的美国合作机构，这从长远来看是合理的 与尼日利亚机构的研究和研究培训合作的历史，以及它在 全球卫生和充足的补充资源。生物医学信息学的具体目标和 统计核心(BISC)是：1.加强现有临床系统(艾滋病毒临床电子数据库和癌症 登记处)开发高质量的门诊艾滋病毒相关癌症电子临床数据收集 和UniJos和UNILAG的住院系统，2.开发协作生物医学信息学和统计 团队专注于为尼日利亚的艾滋病毒相关癌症遗传学研究提供核心服务，以及3.提供 拟议监督和支持项目1(CC)和项目2(CERACH)的信息学和统计需求 在这条U54公路下。在该BISC下，将协调电子数据收集和管理能力 整合成一个单一的癌症研究信息系统(CRIS)。CRIS将包括以下方面：(1)数据 收集，(2)需求评估和社区参与的调查分发，(3)沟通和 BISC协调，(4)财务/赠款管理，(5)数据管理和质量保证，(6)联系 临床数据和研究生物样品库样本，(7)研究建议的跟踪/遵从性，以及 (8)BISC服务的跟踪和结果。还将开发以下BISC服务：集中化 数据整合和管理、计算设施和生物统计咨询。的总目标是 BISC将支持和促进项目1(肝细胞癌)和项目2(宫颈)中提出的研究，提供设施 对于职业促进核心(CEC)下的培训活动，与 病理学和基因组学核心(PGC)，与行政部门一起构建基础设施和研究管理 核心(AC)。