Center for the Biologic Basis of Oral/Systemic Diseases (Phase III)

描述（由申请人提供）：全身性疾病（CBBO/SD）是肯塔基大学内具有全国竞争力的跨学科研究中心，专注于口腔健康科学和全身性疾病。该提案建立在用于发展牙科学院研究基础设施和支持初级研究人员利用该基础设施开发有竞争力的研究项目的i /ll阶段资金的基础上。CBBO/SD代表了1 / 11期资助的具体目标的具体实现，旨在：(i)扩大英国口腔和全身健康研究领域受资助研究人员的临界质量；（ii）创造和加强尖端的科学核心资源，这些资源可以继续作为平台，提高现有研究人员的竞争力，并招募新的研究人员；（iii）在研究企业中实施一系列基础设施改进，以成功地将COBRE资金转化为来自各种联邦和非联邦来源的长期有竞争力的可再生支持。从2000年开始，UKCD设立了一个研究副院长的职位，并在学院设立了一个口腔健康研究中心（COHR），以开发和监督广泛的基础和应用研究。随后的事件为2003年实施CBBO/SD创造了一个充满活力的环境，其明确目标是在牙科学院建立一个进行口腔和全身健康研究的中心。CBBO/SD提供强大的专题研究重点和独特的资源，以及研究生，博士后研究员和初级教师指导的研究培训。从一开始，这是在一个强调指导、科学进步、学术生涯发展、竞争性资助和生产力的协作框架中完成的。第三阶段提案包括4个互动核心：行政/教育核心，肯塔基州临床研究中心三角洲牙科（DDKCRC）核心；核心转化诊断实验室；口腔健康试点项目（OI-IPP）的核心。CBBO/SD第ii期的目标是：(1)集中精力和资源，建立一个可持续发展的大学范围内的研究中心，拥有独特的临床和转化科学核心，在口腔和一般健康调查方面提供跨学科研究互动；(2)继续识别、激励和培养肯塔基大学的研究人员，以确定和追求与口腔和颅面复杂疾病相关的重要问题；(3)通过提供支持这些研究计划的专业核心设施的结构和专业知识，加强合作研究计划的扩展。CBBO/SD的主要研究主题通常与中心第一/二阶段任期内的研究主题相似。这集中在慢性炎症性疾病感染和失调的宿主反应连接口腔和全身健康。CBBO/SD有一个平行的目标，即为英国牙科学院（UKCD）的研究事业提供基本基础，以积极参与国家临床和转化研究环境，重点是通过加强新的临床发现的实施，将临床发现转化为改善人口健康。作为肯塔基州联邦的旗舰赠地大学，UKCD通过解决肯塔基州阿巴拉契亚地区几代人的口腔和一般健康差异，在帮助解决居住在肯塔基州54个县的阿巴拉契亚人口的大量医疗保健需求方面发挥着重要作用。这将需要有效的跨专业教育、合作研究计划，并强调来自广泛的NIH研究所、其他联邦机构以及独立的私人和公共资金来源的外部资金。该中心第三阶段的战略目标包括：了解牙周病的分子机制；促进合作，确定将牙周病与全身性疾病联系起来的生物学机制；支持英国校区的合作努力，让更多的研究团队参与提供遗传学/基因组学服务和矿化组织服务；并继续与英国临床和转化科学中心保持研究关系，实施以社区为基础的倡议，以减轻口腔疾病负担。

DESCRIPTION (provided by applicant): Systemic Diseases (CBBO/SD)" is to continue sustainability of a nationally competitive transdisciplinary research center focusing on oral healt sciences and systemic diseases within the University of Kentucky. This proposal builds upon the Phase l/ll funding for developing the research infrastructure in the College of Dentistry and supporting junior investigators to develop competitive research programs using this infrastructure. The CBBO/SD represents the concrete realization of the Specific Aims of the Phase l/ll funding that was designed to: (i) expand the critical mass of funded investigators at UK in the areas of oral and systemic health research; (ii) create and enhance cutting-edge scientific core resources that can continue to serve as platforms to increase the competitiveness of existing research faculty, as well as for recruiting new faculty; and (iii) implement the range f infrastructure improvements in the research enterprise to successfully transition the COBRE funding into long-term competitive, renewable support from a diverse array of federal and non-federal sources. The UKCD created a position for an Associate Dean for Research, and a Center for Oral Health Research (COHR) housed in the college to develop and oversee a broad range of basic and applied research beginning in 2000. This was followed by events that created a vibrant environment for implementation of the CBBO/SD in 2003 with an explicit goal of developing a center conducting research on oral and systemic health and housed in the College of Dentistry. The CBBO/SD provides a strong thematic research focus and unique resources, along with research training of graduate students, post-doctoral fellows, and junior faculty mentoring. From the outset this was accomplished in a collaborative framework that emphasized mentoring, scientific advancement, academic career development, competitive grantsmanship, and productivity. The Phase III proposal incorporates 4 interactive cores: Adminstrative/Educational Core, Delta Dental of Kentucky Clinical Research Center (DDKCRC) Core; Core Translational Diagnostics Laboratory (CTDL); and Oral Health Pilot Program (OI-IPP) core. The CBBO/SD Phase Ill objectives are to: (1) focus efforts and resources towards creating a sustainable university-wide research center with unique clinical and translational scientific cores providing interdisciplinary research interactions in oral and general health investigations, (2) continue to identify, Stimulate and nurture investigators at the University of Kentucky to ascertain and pursue important questions related to diseases of the oral and craniofacial complex, and (3) enhance the expansion of collaborative research programs by supplying structure and expertise in specialized core facilities supporting these research initiatives. The major research theme of the CBBO/SD generally remains similar to those throughout the Phase l/ll tenure of the center. This focused on chronic inflammatory diseases with infections and dysregulated host responses linking oral and systemic health. The CBBO/SD has a parallel goal in providing the fundamental basis for the research enterprise in the UK College of Dentistry (UKCD) to actively participate in the national clinical and translation research environment with a focus of moving clinical findings into improving health of the population with enhanced implementation of new clinical findings. As the flagship land-grant University of the Commonwealth of Kentucky, the UKCD has a major role in helping to solve the massive health care needs of the Appalachian population inhabiting 54 counties in Kentucky by addressing multigenerational oral and general health disparities in Appalachian Kentucky. This will require effective interprofessional education, collaborative research initiatives, and emphasizing external funding from a wide array of NIH institutes, other federal agencies, and independent private and public funding sources. The Strategic Objectives of the Phase III aspect of the center include: understand the molecular mechanisms underlying periodontal disease; foster collaborations enabling definition of the biologic mechanisms linking periodontal disease with systemic disease(s); support collaborative efforts across the UK campus to engage additional research teams into the offering of the Genetics/Genomics services and the Mineralized Tissue services; and, continue the research relationship with the Center for Clinical and Translational Sciences at UK to implement community-based initiatives to reduce oral disease burden.