Center for the Biologic Basis of Oral/Systemic Diseases (Phase III)

描述（由申请人提供）：“系统性疾病 (CBBO/SD)”旨在继续维持肯塔基大学内具有全国竞争力的跨学科研究中心，专注于口腔健康科学和系统性疾病。该提案建立在用于开发牙科学院研究基础设施的 I/II 期资金基础上，并支持初级研究人员利用该基础设施开发竞争性研究项目。CBBO/SD 代表了 I/II 期资金具体目标的具体实现，该资金旨在： (i) 扩大英国在口腔和系统健康研究领域受资助的研究人员的数量；(ii) 创建和增强尖端科学核心资源，这些资源可以继续作为提高现有研究人员竞争力以及招募新教员的平台；(iii) 在研究企业中实施一系列基础设施改进，以成功地将 COBRE 资助转变为来自各种联邦和非联邦来源的长期竞争性、可再生支持。自 2000 年起，学院内设立了一个口腔健康研究中心 (COHR)，负责开发和监督广泛的基础和应用研究。随后的一系列活动为 2003 年的 CBBO/SD 的实施创造了充满活力的环境，其明确目标是建立一个位于牙科学院的中心，开展口腔和系统健康研究。CBBO/SD 提供强大的主题研究重点和独特的资源，以及对研究生、博士后的研究培训。从一开始，这一项目就在一个强调指导、科学进步、学术职业发展、竞争性资助和生产力的合作框架中完成，该项目包含 4 个互动核心：行政/教育核心、肯塔基州临床研究中心 (DDKCRC) 核心、核心转化诊断实验室 (CTDL) 和口腔健康试点计划 (OI-IPP) 核心。目标是：（1）集中精力和资源创建一个可持续的全校研究中心，具有独特的临床和转化科学核心，在口腔和一般健康调查中提供跨学科研究互动，（2）继续识别、激励和培养肯塔基大学的研究人员，以确定和探索与口腔和颅面复合体疾病相关的重要问题，以及（3）通过提供支持这些研究计划的专业核心设施的结构和专业知识，加强合作研究项目的扩展。 CBBO/SD 总体上与中心的整个 I/II 阶段的研究相似，重点关注与口腔和全身健康相关的慢性炎症性疾病和宿主反应失调。 CBBO/SD 的共同目标是为英国牙科学院 (UKCD) 的研究企业积极参与国家临床和转化研究环境提供基础基础，重点是通过加强新临床发现的实施，将临床发现转化为改善人群的健康。 UKCD 在帮助解决肯塔基州 54 个县的阿巴拉契亚人口的巨大医疗保健需求方面发挥着重要作用，解决阿巴拉契亚肯塔基州的多代口腔和一般健康差异，这将需要有效的跨专业教育、合作研究计划，并强调来自各种 NIH 机构、其他联邦机构以及独立的私人和公共资金来源的外部资金。该中心的第三阶段方面包括：了解牙周病的分子机制；促进合作，确定牙周病与全身性疾病之间的生物学机制；支持英国校园内的合作努力，让更多的研究团队参与提供遗传学/基因组学服务和矿化组织服务；并继续与英国临床和转化科学中心建立研究关系，以实施基于社区的举措，以减轻口腔疾病负担。

DESCRIPTION (provided by applicant): Systemic Diseases (CBBO/SD)" is to continue sustainability of a nationally competitive transdisciplinary research center focusing on oral healt sciences and systemic diseases within the University of Kentucky. This proposal builds upon the Phase l/ll funding for developing the research infrastructure in the College of Dentistry and supporting junior investigators to develop competitive research programs using this infrastructure. The CBBO/SD represents the concrete realization of the Specific Aims of the Phase l/ll funding that was designed to: (i) expand the critical mass of funded investigators at UK in the areas of oral and systemic health research; (ii) create and enhance cutting-edge scientific core resources that can continue to serve as platforms to increase the competitiveness of existing research faculty, as well as for recruiting new faculty; and (iii) implement the range f infrastructure improvements in the research enterprise to successfully transition the COBRE funding into long-term competitive, renewable support from a diverse array of federal and non-federal sources. The UKCD created a position for an Associate Dean for Research, and a Center for Oral Health Research (COHR) housed in the college to develop and oversee a broad range of basic and applied research beginning in 2000. This was followed by events that created a vibrant environment for implementation of the CBBO/SD in 2003 with an explicit goal of developing a center conducting research on oral and systemic health and housed in the College of Dentistry. The CBBO/SD provides a strong thematic research focus and unique resources, along with research training of graduate students, post-doctoral fellows, and junior faculty mentoring. From the outset this was accomplished in a collaborative framework that emphasized mentoring, scientific advancement, academic career development, competitive grantsmanship, and productivity. The Phase III proposal incorporates 4 interactive cores: Adminstrative/Educational Core, Delta Dental of Kentucky Clinical Research Center (DDKCRC) Core; Core Translational Diagnostics Laboratory (CTDL); and Oral Health Pilot Program (OI-IPP) core. The CBBO/SD Phase Ill objectives are to: (1) focus efforts and resources towards creating a sustainable university-wide research center with unique clinical and translational scientific cores providing interdisciplinary research interactions in oral and general health investigations, (2) continue to identify, Stimulate and nurture investigators at the University of Kentucky to ascertain and pursue important questions related to diseases of the oral and craniofacial complex, and (3) enhance the expansion of collaborative research programs by supplying structure and expertise in specialized core facilities supporting these research initiatives. The major research theme of the CBBO/SD generally remains similar to those throughout the Phase l/ll tenure of the center. This focused on chronic inflammatory diseases with infections and dysregulated host responses linking oral and systemic health. The CBBO/SD has a parallel goal in providing the fundamental basis for the research enterprise in the UK College of Dentistry (UKCD) to actively participate in the national clinical and translation research environment with a focus of moving clinical findings into improving health of the population with enhanced implementation of new clinical findings. As the flagship land-grant University of the Commonwealth of Kentucky, the UKCD has a major role in helping to solve the massive health care needs of the Appalachian population inhabiting 54 counties in Kentucky by addressing multigenerational oral and general health disparities in Appalachian Kentucky. This will require effective interprofessional education, collaborative research initiatives, and emphasizing external funding from a wide array of NIH institutes, other federal agencies, and independent private and public funding sources. The Strategic Objectives of the Phase III aspect of the center include: understand the molecular mechanisms underlying periodontal disease; foster collaborations enabling definition of the biologic mechanisms linking periodontal disease with systemic disease(s); support collaborative efforts across the UK campus to engage additional research teams into the offering of the Genetics/Genomics services and the Mineralized Tissue services; and, continue the research relationship with the Center for Clinical and Translational Sciences at UK to implement community-based initiatives to reduce oral disease burden.