Multiuser Image-guided small animal X-ray Platform.

我们正在申请资金购买一个SARRP图像引导X射线平台，以便继续支持 共有26个研究项目。在目前资助的需要使用辐照器的项目中， 它们是NIH RO 1、一个PO 1和一个U-42项目。此外，一项FDA资助的1/2期研究获得批准， 四个可能获得资助的NIH RO 1项目（目前正在理事会审查中）建议使用 辐照器除此之外，其他四个联邦资助的项目（美国国防部，退伍军人， 政府）和六个国家或机构资助的项目取决于辐照器的使用。业绩和 当前辐照器使用的生产率对于包括期刊在内的开创性出版物具有重要意义 性质，Mol.细胞生物学，生物化学杂志，PNAS和癌症研究。作为一个额外的好处，辐射设施 与其他机构的核心设施，包括机构转基因核心平台相结合。目前 研究人员在伽马细胞-40辐照器中对生物样品进行辐照， 自1980年以来一直在使用。截至2010年3月，制造商宣布这台已有35年历史的137 Cs源辐照器 一个有用的生命周期结束，并通知该公司不能再保证更换零件，这一旧的 单位它定期显示错误的门锁系统和空气压力，导致不适当的定位， 曝光头或过度曝光，由于未能打开门。当安全系统启动时，由于 不安全的门锁，有时，系统无法打开。此外，由于这几十年的老设备， 没有规定局部照射或靶向输送，无法满足几个要求 当前和新的研究。与旧的辐照器不同，SARRP 200可用于动物 除了老鼠。内置的固定系统允许用户在麻醉下暴露动物 这是当前辐照器无法实现的条件。SARRP图像引导辐照器平台没有 放射源，并专门设计为生物研究的Cs替代品。此外，SARRP 与其主要的商业竞争对手相比，它有几个优势。SARRP 200辐照系统 选择其性能更适合当前和未来的用户，在几个实验室中广泛使用，安全， 耐久性、自屏蔽性和使用寿命。我们有一个精心组成的内部咨询委员会 用于辐射器的生产性操作一段延长的时间。在强大的制度支持下 和技术专长，通过运行辐照器在过去的几年里，我们有信心，我们可以努力 操作辐照器，支持当前项目，满足来料的挑战/要求 今后的研究。来自医学院和NCI的医生都指定了癌症治疗研究 中心（CTRC）和UTHSCSA研究生院的多个NIH项目的翻译/基础科学家 生物医学科学可以充分利用这种设备。

We are requesting funds to purchase a SARRP image-guided x-ray platform in order to continually support a total of 26 research projects. Among the currently funded projects that requires the use of the irradiator, nine of them are NIH RO1, one PO1 and one U-42 projects. Additionally, one funded FDA approved phase1/2 study and four NIH RO1 projects that are likely to get funded (currently under council review) proposed to use the irradiator. Apart from that, four other federally funded projects (US Department of Defense, Veteran Administration) and six state- or institutional-funded project depend on the irradiator use. The track record and productivity out of the current irradiator use is significant with seminal publications including the journals Nature, Mol. Cell Biol., J Biol. Chem., PNAS, and Cancer Research. As an added benefit, the irradiation facility is integrated with other institutional core facilities including institutional transgenic core platform. Currently the investigators perform their radiation exposures for biological samples in a Gamma Cell-40 irradiator which has been in use since 1980. As of March 2010, the manufacturer proclaimed this 35-year old 137Cs source irradiator an end-of-useful lifecycle and informed that the company can no longer guarantee replacement parts on this old unit. It periodically shows a faulty door-lock system and air pressure resulting in inappropriate positioning of the exposures heads or over exposure due to failure in unlocking the door. When safety system kicks-in, due to unsecured door locks, sometimes, system fails to switch on. In addition, since this decades-old equipment has no provision for partial body irradiation or targeted delivery, it is unable to meet the requirements of several current and newly approaching research studies. Unlike the old irradiator SARRP 200 can be used for animals other than mice. Built-in immobilization system allows the users to expose the animals under anesthetic condition which is not possible with the current irradiator. The SARRP image guided irradiator platform has no radioactive source and is designed specifically as Cs replacement for biological research. Additionally, SARRP has several advantageous over its principal commercial competitors. The SARRP 200 irradiation system is chosen for its performance more suited for the current and future users, wide use in several laboratories, safety, durability, self-shielding, and its useful life time. We have a carefully constituted an internal advisory committee for a productive operation of the irradiator for an extended period of time. With a strong institutional support and technical expertise by running the irradiator for the past several years we are confident that we can diligently operate the irradiator and support the current projects and meet the challenges/ requirements of incoming studies in future. Both physicians from the Medical School and the NCI designated Cancer Therapy Research Center (CTRC), and translational/basic scientists with multiple NIH projects from UTHSCSA Graduate School of Biomedical Sciences can take full advantage of this equipment.