Human Subjects and Data Integration Core

项目摘要 人的主体和数据集成核心将为人力资源的招聘提供核心资源 参与CF和哮喘粘液病理的临床研究以及综合多个 计划来源，以促进沟通和促进翻译计划。招募人类受试者 以机制为导向的临床研究方案需要良好的系统来确保受试者的成功 从特征良好的人类受试者中招募和收集高质量的生物标本。Dr。 Stephen Lazarus-一位经验丰富的临床研究人员，现任加州大学旧金山分校哮喘网和加州大学旧金山分校的PI COPD CCRN-将指导核心，它将有两个目标。他的核心B团队将包括以下人员 在肺部医学、临床研究管理、临床协调、生物统计学和 数据管理。核心将有两个具体目标：目标1将招募和招收人类受试者 支持三个tPPG项目的临床研究方案。具体地说，实现项目的临床目标 1、2和3，核心将负责招募和登记患有哮喘、CF和健康的参与者 控制和为将由CRO专家进行的1a阶段研究提供支持。目标2将会发展 并维护tPPG的综合数据管理和集成系统。具体地说，Aim 2将 开发数据集成平台，实现跨合作机构的高效实时数据共享 并确保合作伙伴项目和机构之间的物理距离不是 这个tPPG的成功。

Project Summary The Human Subjects and Data Intergration Core will provide a core resource for the recruitment of human participants for clinical studies of mucus pathology in CF and asthma and for intergrating data from multiple program sources to facilitate communication and promote the translation plan. Recruiting human subjects for mechanism-oriented clinical research protocols requires well-developed systems to ensure successful subject recruitment and the collection of high quality biospecimens from well-characterized human subjects. Dr. Stephen Lazarus - a highly experienced clinical researcher - currently PI of UCSF AsthmaNet and UCSF COPD CCRN - will direct the core, which will have two Aims. His Core B team will include personnel with experience in pulmonary medicine, administration of clinical research, clinical coordination, biostatistics and data management. The core will have two specific Aims: Aim 1 will recruit and enroll human subjects for clinical research protocols to support the three tPPG projects. Specifically, to fulfill the clinical aims of Projects 1, 2, and 3, the core will be responsible for recruiting and enrolling participants with asthma, CF, and healthy controls and in providing support for a Phase 1a study to be performed by a specialist CRO. Aim 2 will develop and maintain an integrated data management and integration systems for the tPPG. Specifically, Aim 2 will develop a data integration platform that will enable efficient real-time data sharing across partner institutions and ensure that physical distances between partner projects and institutions are not a limiting factor in the success of this tPPG.