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2017 Grover Conference

2017年格罗弗会议

基本信息

批准号：
9331900
负责人：
Konstantin Birukov
金额：
$ 1万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9331900
关键词：
Address Adult Respiratory Distress Syndrome American Basic Science Biology Blood Vessels Calendar Cardiopulmonary Cell Communication Cell Proliferation Cells Cellular biology Chronic Obstructive Airway Disease Clinical Clinical Medicine Collaborations Communication Communities Data Data Analyses Development Developmental Biology Disease Doctor of Philosophy Emerging Technologies Endothelium Environment Epigenetic Process Event Faculty Formulation Functional disorder Funding Future Genetic Genomics Goals Health Heart failure Heterogeneity Homeostasis International Interstitial Lung Diseases Investigation Journals Knowledge Lead Leadership Lung Lung diseases Manuscripts Mechanics Mentors Metabolic Mission Molecular Molecular Biology Names National Heart, Lung, and Blood Institute North America Pathogenesis Pathologic Pathologic Processes Pathology Phenotype Process Pulmonary Circulation Pulmonary Heart Disease Pulmonary Hypertension Pulmonary Pathology Recovery Research Research Personnel Right Ventricular Dysfunction Right ventricular structure Role Science Scientist Series Signal Transduction Stress Students Systems Biology Techniques Technology Therapeutic Time United States National Institutes of Health Vascular Diseases Vascular Endothelium Ventricular base biomarker development biomarker identification career development cell type congenital heart disorder disease phenotype injury and repair insight interest lectures lung injury lung repair meetings new therapeutic target next generation sequencing novel posters programs rural setting senior faculty symposium therapeutic target translational scientist

项目摘要

PROJECT SUMMARY The proposed 2017 Grover Conference "Endothelium at the frontline of Vascular Pathobiology and Therapeutic Targeting in Lung Vascular Disease" will bring together established investigators and junior scientists (junior faculty, fellows, and students) in an interactive forum in which multiple roles of pulmonary endothelium in health and disease will be discussed with the goal to determine major pathologic mechanisms triggered by disturbed endothelium and define future therapeutic strategies to confront un-curable lung diseases associated with major dysfunctions of pulmonary circulation such as PAH, COPD and ARDS. There will be 34 confirmed national and international speakers presenting most recent findings and new concepts. Specific emphasis will be made on vascular endothelium in progression and reversal of lung disease and reflected in the following main discussion topics: 1) Phenotypic diversity and the role of the vascular endothelium in the initiation of lung injury and repair; 2) Multi-faceted role of the pulmonary circulation and specifically, the vascular endothelium in the pathogenesis and modulation of lung diseases (ALI/ARDS, PH, COPD, ILD and CF); 3) Role of lung endothelial micro- and macro-environment and communication between different vascular cell types in PAH and ARDS; 4) Metabolic dysregulation in vascular endothelium and its impact in pathogenesis of PAH and ARDS; 5) Broader investigation of endothelial involvement in pulmonary circulation-related abnormalities in other lung diseases; 6) Formulation of future endothelial-centric research directions to treat lung disease. The need for this meeting is high, since there are no other meetings with this scientific focus held in North America. We anticipate participation by researchers (both MD and PhD) and research-oriented clinicians interested in pulmonary hypertension, ARDS, COPD, interstitial lung disease right heart failure, congenital heart disease, developmental biology as well as basic and translational researchers interested in the intersection of cell, molecular biology with cardiopulmonary diseases. To enhance participation of junior scientists, the program includes several short talks each day based on selected best abstracts. In addition to the key lectures, there will be poster sessions in the afternoons to allow students, fellows and junior faculty to present their research in an informal setting. To facilitate interactions between junior and established investigators, roundtable discussions will be held prior to poster sessions—senior investigators will be assigned to lead these sessions. This process will allow junior investigators dedicated time to meet with the conference organizers, session chairs, and any NIH representatives in attendance. Each invited speaker will be required to submit a manuscript describing their topic and appropriate related information to the journal Pulmonary Circulation, the leading journal in pulmonary community focused on vascular aspects of lung pathologies.

项目总结