Regulation of LAIR-1 in Lupus

描述(申请人提供)：系统性红斑狼疮(SLE)是一种自身免疫性疾病，既有遗传因素，也有非遗传因素。已知C1q缺乏易患系统性红斑狼疮，表明C1q有助于维持耐受性。研究表明，C1q可激活白细胞相关免疫球蛋白样受体-1(LAIR-1)，为理解C1q介导的耐受机制提供了合理的线索。我们最近的研究表明，丁酸上调了LAIR-1的表达。这项研究的目标是了解LAIR-1是如何调节的，以及它与C1q一起如何有助于疾病预防。这些研究可能有助于确定SLE的潜在治疗靶点。因此，我们建议：1.了解C1q介导的LAIR-1激活机制。2.了解调控LAIR-1表达的因素。3.检测LAIR-1对狼疮模型的作用。通过对三个相关问题的研究，我们将进一步定义SLE发病机制的新的生物学和临床见解。

DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is an autoimmune disease that has both genetic and nongenetic triggers. C1q deficiency is known to predispose to SLE, demonstrating that C1q helps maintain tolerance. Studies showing that C1q triggers leukocyte-associated Ig-like receptor-1 (LAIR-1) activation have yielded some reasonable clues for understanding tolerance mechanisms mediated by C1q. Our recent studies have revealed that butyrate up-regulates the expression of LAIR-1. The goal of this study is to understand how LAIR-1 is regulated and how it, together with C1q, contributes to disease prevention. These studies may help identify potential therapeutic targets in SLE. We therefore propose to: 1. Understand the mechanism of C1q-mediated LAIR-1 activation. 2. Understand factors regulating expression of LAIR-1. 3. Test the contribution of LAIR-1 to lupus models. By studying three relevant questions, we will further define new biological and clinical insights of SLE pathogenesis.