Synthetic Antigen Binder Core

合成抗体结合剂Sab核心的总体目标是开发广泛的 一系列强大的方法，并提供新的试剂，以支持该联盟的 社区的研究目标。Sab核心是独一无二的， 一种高通量的方式合成抗体（Sabs），以广泛的目标 包括可溶性蛋白、蛋白复合物和膜蛋白。因此 具备广泛能力的基础设施到位，能够有效地产生高质量的亲和力 试剂，将大大加快膜蛋白的研究进行内 MPSDC联盟，以及整个膜蛋白研究界。 Sab核心的目标是（i）提供高质量的合成亲和试剂， 使用最先进的技术的膜蛋白靶，（ii）加速结构 通过Sab-assisted结晶学和Cryo-EM测定和（iii）开发新的 SAP的应用程序，这将使核心用户能够显着提高 对膜蛋白功能的机械理解。

The overarching goal of the Synthetic Antibody Binder Sab Core is to develop a broad range of powerful approaches and provide novel reagents to support the consortium¹s and community¹s research objectives. The Sab Core is uniquely capable to generate in a high-throughput way synthetic antibodies (Sabs) to an extensive range of targets including soluble proteins, protein complexes and membrane proteins. Thus, the infrastructure in place with extensive capability to efficiently generate high-quality affinity reagents that will dramatically accelerate membrane protein research performed within the MPSDC Consortium, as well as in the entire membrane protein research community. The goals of the Sab Core are (i) to provide high-quality synthetic affinity reagents for membrane protein targets using state-of-the-art technologies, (ii) to accelerate structure determination by Sab-assisted crystallography and Cryo-EM and (iii) to develop novel applications of Sabs that will enable Core users to significantly elevate the level of mechanistic understanding of membrane protein functions.