Breeding Colony Management Services

育种群体管理服务

• 批准号: 9207537
• 负责人: Jeremy V. Smedley
• 金额: $ 44.34万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9207537
• 关键词: Alleles; Animal Model; Animal Welfare; Animals; Antigens; Blood Coagulation Disorders; Breeding; Cluster Analysis; Coccidioides immitis; Coccidioidomycosis; Computer software; Data; Databases; Disease susceptibility; Ensure; Equilibrium; Family suidae; Female; Funding; Generations; Genetic; Genetic Variation; Genotype; Goals; Grant; HIV; Haplotypes; Harvest; Inbreeding; Infectious Agent; International; Location; Macaca; Macaca nemestrina; Maintenance; Microsatellite Repeats; Modeling; Newborn Infant; Organism; Partner in relationship; Phenotype; Population; Primates; Production; RNA analysis; Research; Research Personnel; Resources; Risk; SRV-1; SRV-2; Secondary Amyloidosis; Serologic tests; Services; Short Tandem Repeat; Simian Retroviruses; Site; Tail; Techniques; Test Result; Testing; Viral; Viral Antigens; Virus; Washington; Western Blotting; case control; cost; desert fever; genetic information; genetic pedigree; human disease; novel; offspring; pathogen; prevent; seropositive; tool; transcriptome sequencing; vaccine development

DIVISION OF PRIMATE RESOURCES: BREEDING COLONY MANAGEMENT SERVICES SUMMARY The Washington National Primate Research Center (WaNPRC) houses the largest domestic breeding colony of pigtailed macaques (M. nemestrina). This breeding colony serves as a national resource to investigators who use M. nemestrina as an animal model for human disease. The Breeding Colony Management Service (BCMS) functions to optimize quality and availability of this resource. Intentional breeding strategies are used to increase production and reduce loss to increase the availability of animals. One consideration with regard to quality is the elimination of infectious organisms that could impact animal welfare or interfere with research. Current organisms of concern are simian retrovirus (SRV) and Coccidioides immitis, the causative organism of Valley Fever, and sophisticated efforts are underway to eliminate these organisms from the breeding colony. Another consideration for quality is maintenance of on outbred colony. An extensive pedigree and state-of-the- art breeding management software are used to ensure genetic diversity. Additionally, cutting edge genetic tools are used to genetically characterize the animals in the WaNPRC M. nemestrina breeding colony and investigate the association of MHC haplotype with disease susceptibility.

灵长类动物资源司： 育种群体管理服务 总结 华盛顿国家灵长类动物研究中心（WaNPRC）拥有最大的国内繁殖群 pigtailed macaques（M.线虫属）。这个繁殖地对调查人员来说是一个国家资源 使用M。nemestrina作为人类疾病的动物模型。繁殖群体管理服务 （BCMS）的功能是优化该资源的质量和可用性。使用了有意的育种策略 增加产量，减少损失，增加动物的可用性。关于以下方面的一项考虑： 质量是消除可能影响动物福利或干扰研究的传染性微生物。 目前关注的生物体是猿猴逆转录病毒（SRV）和粗球孢子菌，粗球孢子菌是引起感染的生物体。 山谷热，和复杂的努力正在进行中，以消除这些生物从繁殖殖民地。 质量的另一个考虑因素是保持远交群体。一个广泛的血统和国家的- 使用先进的育种管理软件，确保遗传多样性。此外，尖端基因 工具被用于在WaNPRC M中对动物进行遗传表征。nemestrina繁殖群体和 探讨MHC单倍型与疾病易感性的关系。