Breeding Colony Management Services

灵长类资源的划分： 繁育群体管理服务 摘要 华盛顿国家灵长类动物研究中心(WaNPRC)拥有国内最大的繁殖群体 指辫尾猕猴(M.nomestrina)。对于研究人员来说，这个繁育的殖民地是一个国家资源 他们用新月形分支杆菌作为人类疾病的动物模型。繁育群体管理服务 (BCMS)的功能是优化该资源的质量和可用性。使用了有意的繁殖策略 增加产量，减少损失，增加动物的可获得性。关于以下方面的一个考虑因素 质量是指消除可能影响动物福利或干扰研究的传染病。 目前令人关注的生物是猴反转录病毒(SRV)和球虫，它是引起人类死亡的 山谷热，目前正在进行复杂的努力，将这些生物从繁殖群体中消除。 对质量的另一个考虑是维持远交种群体。广泛的血统和最先进的- 采用ART育种管理软件，确保遗传多样性。此外，尖端的基因 工具被用来对WaNPRC M.nomestrina繁育群体中的动物进行遗传学特征描述和 研究MHC单倍型与疾病易感性的关系。

DIVISION OF PRIMATE RESOURCES: BREEDING COLONY MANAGEMENT SERVICES SUMMARY The Washington National Primate Research Center (WaNPRC) houses the largest domestic breeding colony of pigtailed macaques (M. nemestrina). This breeding colony serves as a national resource to investigators who use M. nemestrina as an animal model for human disease. The Breeding Colony Management Service (BCMS) functions to optimize quality and availability of this resource. Intentional breeding strategies are used to increase production and reduce loss to increase the availability of animals. One consideration with regard to quality is the elimination of infectious organisms that could impact animal welfare or interfere with research. Current organisms of concern are simian retrovirus (SRV) and Coccidioides immitis, the causative organism of Valley Fever, and sophisticated efforts are underway to eliminate these organisms from the breeding colony. Another consideration for quality is maintenance of on outbred colony. An extensive pedigree and state-of-the- art breeding management software are used to ensure genetic diversity. Additionally, cutting edge genetic tools are used to genetically characterize the animals in the WaNPRC M. nemestrina breeding colony and investigate the association of MHC haplotype with disease susceptibility.