Biostatistics

生物统计核心的目的是与孢子研究人员在他们的研究项目上合作 并监督临床试验的进行。具体地说，生物统计核心将开发统计 设计、制定统计分析计划、进行数据采集、开发数据库、归档数据、 开发临床研究表格，对涉及人类受试者的临床试验进行数据监测，执行 数据分析和解释，并协助编写手稿、摘要和演示文稿。 这一目标将通过以下具体目标来实现：1)与孢子合作 研究人员进行研究设计，以开发具有适当统计操作特征的项目2) 为每个孢子项目提供统计分析计划3)对项目结果进行统计分析 根据统计分析计划的规定，并与孢子调查人员合作进行解释 和报告研究结果4)监督孢子临床研究项目的进行，以确保 患者安全和项目的科学完整性5)与孢子调查人员合作 解释数据分析结果并协助编写手稿、摘要和 演示文稿。 已经组建了一个由两名教员和两名受过硕士培训的生物统计学家组成的团队，以满足一系列 项目的统计方法和分析需求，包括设计和分析项目的专门知识 高维数据和临床试验。该团队将确保设计和分析是适当的 以达到项目的目标，这对孢子的成功至关重要。生物统计学的核心将 由Jane Meza博士指导，额外配备方宇博士(专门从事高维 数据分析)，Lynette Smith M.S.(受过硕士培训的高维数据生物统计学家 分析)和罗宾高中硕士(硕士培养的生物统计学家)。

The purpose of the Biostatistics Core is to collaborate with SPORE investigators on their research projects and to monitor the conduct of the clinical trials. Specifically, the Biostatistics Core will develop statistical designs, develop statistical analysis plans, perform data acquisition, develop databases, archive data, develop clinical research forms, perform data monitoring for clinical trials involving human subjects, perform data analysis and interpretation and aid in the development of manuscripts, abstracts and presentations. This purpose will be accomplished through the following specific aims: 1) Collaborate with SPORE investigators on study design to develop projects with appropriate statistical operating characteristics 2) Provide a statistical analysis plan for each SPORE project 3) Perform statistical analyses of project results as specified in the statistical analysis plan and collaborate with SPORE investigators on the interpretation and reporting of research findings 4) Monitor the conduct of SPORE clinical research projects to ensure patient safety and the scientific integrity of the projects 5) Collaborate with SPORE investigators on interpretation of data analysis results and aid in the development of manuscripts, abstracts and presentations. A team of two faculty and two Masters-trained biostatisticians has been assembled to meet the range of statistical methodological and analytical needs of the projects, including expertise in design and analysis of high-dimensional data and clinical trials. This team will ensure that the design and analyses are appropriate to meet the aims of the projects, which is essential to the success of the SPORE. The Biostatistics Core will be directed by Jane Meza Ph.D. and additionally staffed by Fang Yu Ph.D. (specializing in high-dimensional data analysis), Lynette Smith M.S. (Masters-trained biostatistician specializing in high-dimensional data analysis) and Robin High M.A. (Masters-trained biostatistician).