Identity by descent in population data

人口数据中的血统身份

• 批准号: 9330892
• 负责人: Sharon Browning
• 金额: $ 35.45万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-25 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9330892
• 关键词: Alleles; Chromosomes; DNA; Data; Demography; Detection; Event; Foundations; Frequencies; Funding; Genetic; Genetic Materials; Genetic Recombination; Genome; Genotype; Haplotypes; Health; Heritability; Human; Inherited; Length; Light; Location; Methodology; Methods; Mutation; Phenotype; Population; Population Genetics; Population Sizes; Process; Recording of previous events; SNP array; Sampling; Series; Testing; Time; Uncertainty; Work; base; density; genetic association; identity by descent; improved; migration; novel; rate of change

Project summary A haplotype is a sequence of alleles on a chromosome. Two haplotypes are identical by descent if they are inherited from a common ancestor. Segments of identity by descent (IBD) are found at high frequency in population samples and can be detected with high accuracy in high density SNP array or sequence data. IBD segments can be used for computationally efficient and accurate estimation in many health-related applications including estimating population genetic parameters and performing genetic association testing. We propose to develop improved methodology for detecting IBD segments, with particular focus on quantifying uncertainty in IBD segment endpoints. We will also develop methods that use IBD segments to estimate mutation rates, migration rates, effective population sizes, and population split times.

项目总结