Wavefront guided customized soft contact lens for highly aberrated eyes

该Fast Track小型企业研究项目的最终目标是改善以下人群的视力 有明显改变角膜形状的异常角膜状况，如圆锥角膜和角膜 移植。角膜形状异常的患者两个较低阶数的震级明显较大 和正常情况下的更高阶像差。即使采用最佳球面-柱面校正， 未矫正的残留高阶像差会导致临床上视觉质量的显著下降。 由于无法进行高精度测量，纠正高阶像差一直是个挑战 并制造具有不规则(非旋转对称)表面的隐形眼镜 侧写。这项研究项目旨在通过开发一种商业等级来解决这些当前的障碍， 大动态范围波前传感器与自由曲面加工技术相结合制作波前导引 定制软性隐形眼镜。在第一阶段，我们将演示自由曲面加工的可行性 制造不规则(非旋转对称)镜片表面轮廓的技术，能够校正较高 顺序像差(阶段1目标1)和最大限度地减少眼睛上晶状体不可预测的平移和旋转 定制与不规则角膜前表面相匹配的晶状体后表面(第一阶段目标 2)。在第二阶段，目标一，我们将开发一种商业级大动态范围波前传感器，配备 使用用户友好的软件进行波前分析和隐形眼镜设计。在阶段2、目标2中，我们将评估 方法通过最小化波前引导透镜的不良影响来最大限度地提高视觉效益 剩余镜头移动对矫正性能的影响。然后，在阶段2、目标3中，我们将比较 这款定制软性隐形眼镜(CustomEyes)适用于那些佩戴软性隐形眼镜的人 圆锥角膜眼球镜片与常规球柱镜联合应用的临床可行性及真实性 波前引导下的个性化软性透镜对圆锥角膜患者的视觉益处。

The ultimate goal of this Fast Track small business research project is to improve the vision of people who have abnormal corneal conditions that substantially alter the corneal shape such as keratoconus and corneal transplant. Patients with abnormal corneal shapes have substantially larger magnitudes of both lower-order and higher-order aberrations compared to normals. Even with optimal sphero-cylindrical correction, the uncorrected residual higher order aberrations cause a clinically significant degradation in visual quality. Correcting the higher order aberrations has been challenging due to both the inability to measure highly aberrated eyes and to manufacture a contact lens with an irregular (non-rotationally symmetrical) surface profile. This research project is designed to address these current barriers by developing a commercial grade, large dynamic range wavefront sensor, together with freeform machining technology to fabricate wavefrontguided customized soft contact lenses. In Phase 1, we will demonstrate the feasibility of freeform machining technology to create an irregular (non-rotationally symmetrical) lens surface profile capable of correcting higher order aberrations (Phase 1 Aim 1) and minimizing unpredictable translation and rotation of the lens on eye by customizing the back surface of the lens matched to the irregular anterior surface of the cornea (Phase 1 Aim 2). In Phase 2, Aim 1, we will develop a commercial-grade large dynamic range wavefront sensor equipped with user-friendly software for wavefront analysis and contact lens design. In Phase 2, Aim 2, we will evaluate methods to maximize the visual benefit with the wavefront-guided lens by minimizing the adverse impact of residual lens movement on correction performance. Then, in Phase 2, Aim 3, we will compare the visual outcomes with this customized soft contact lens (CustomEyes) to those with soft contact lenses designed to fit keratoconic eyes but with conventional sphero-cylindrical optics to determine the clinical feasibility and the true visual benefit provided by the wavefront guided customized soft lens in keratoconus patients.