Lipoxins protect against diabetes associated atherosclerosis

脂氧素可预防糖尿病相关的动脉粥样硬化

• 批准号: nhmrc : GNT1159460
• 金额: $ 93.68万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipoxins-protect-diabetes-associated-atherosclerosis/1379075
• 关键词: Lipoxins; protect; against; diabetes; associated

Vascular disease is a major cause of mortality in diabetes. Current treatments are inadequate as cardiovascular disease still represents more than 70% of mortality in people with diabetes. Our exciting new data demonstrate that a novel endogenous small molecule (Lipoxin A4) has protective effects against the pathological processes within vascular cells that drive atherosclerosis. This represents a promising approach to combat diabetic complications such as diabetes-associated atherosclerosis.

血管疾病是糖尿病死亡的主要原因。目前的治疗是不够的，因为心血管疾病仍然占糖尿病患者死亡率的70%以上。我们令人兴奋的新数据表明，一种新的内源性小分子（脂氧素A4）对血管细胞内驱动动脉粥样硬化的病理过程具有保护作用。这代表了对抗糖尿病并发症如糖尿病相关动脉粥样硬化的有希望的方法。