Lipoxins protect against diabetes associated atherosclerosis

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Vascular disease is a major cause of mortality in diabetes. Current treatments are inadequate as cardiovascular disease still represents more than 70% of mortality in people with diabetes. Our exciting new data demonstrate that a novel endogenous small molecule (Lipoxin A4) has protective effects against the pathological processes within vascular cells that drive atherosclerosis. This represents a promising approach to combat diabetic complications such as diabetes-associated atherosclerosis.