A Viable Solution for a See and Treat Paradigm for Cervical Pre-cancer in Africa
非洲宫颈癌前病变“即见即治”模式的可行解决方案
基本信息
- 批准号:9302705
- 负责人:
- 金额:$ 20.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAcetic AcidsAcidsAdoptionAffectAfricaAlgorithmsBiopsyBiopsy SpecimenCalibrationCapitalCare Technology PointsCaringCervicalCervical Cancer ScreeningCervical dysplasiaCervix NeoplasmsCervix UteriCessation of lifeClinicClinicalClinical ResearchCold TherapyCollaborationsColposcopesColposcopyColumnar EpitheliumCommunitiesConsumptionCountryDataDevicesDiagnosisDiffuseDiseaseEarly DiagnosisEarly treatmentEnsureEyeGoalsGoldGuidelinesHandHealthHemoglobinHistopathologyHospitalsHuman PapillomavirusHuman ResourcesImageIncidenceIncomeLesionLinkLoop electrosurgical excision procedureMaintenanceMalignant neoplasm of cervix uteriMeasurementMeasuresMedical centerMethodsMicroscopeModelingMorphologyOpticsOxygenPap smearPathologistPathologyPatientsPerformancePersonsPhasePhysiciansPhysiologyPilot ProjectsPremalignantPrimary Health CareProceduresPublic HealthQualitative MethodsRecording of previous eventsRegulationReproducibilityResearchResearch InfrastructureResourcesSensitivity and SpecificitySiteSpecificitySpectrum AnalysisSpottingsStratificationStratified Squamous EpitheliumSystemTanzaniaTechnologyTestingTimeTissuesTrainingVisible RadiationVisionVisitVisualWomanabsorptionarmbasecervical cancer preventionclinical investigationcostdensitydigitalexperienceglobal healthimprovedin vivolow and middle-income countriesmortalityneovascularizationportabilitypressurepublic health relevancescreeningsensorspectroscopic datastandard of caresuccesstemporal measurementtumor progression
项目摘要
DESCRIPTION (provided by applicant): There is a critical global need for a See and Treat paradigm for cervical cancer that is effective in low-and middle-income communities (LMIC). Guidelines have been written by the Alliance for Cervical Cancer Prevention (ACCP) on strategies for screening cervical cancer in resource-limited settings. Visual inspection with aceti acid (VIA) or VIA with low power magnification (VIAM) combined with cryotherapy or Loop Electrosurgical Procedure (LEEP) appears to be the most viable option for reducing the mortality associated with cervical cancer in the low and middle income countries (LMICs). The colposcope, a low magnification microscope has been historically used for (VIAM) in women with an abnormal Pap smear. Sites that display acetowhitening are biopsied and evaluated by a pathologist. The cervix is treated with LEEP if pre-cancerous lesions are found. In LMICs, this approach is not practical due to the lack of infrastructure and resources and also due to patient attrition at each level of care. Thus it is critical to develop point of care technologies that enale a see and treat paradigm in a single visit within the local communities where the women live. Our long-term goal is to leverage community-clinics as a way to bring early detection and treatment of cervical pre-cancer to as many patients as possible in LMICs particularly in places where hospitals are not easily accessible. We propose to implement a portable, point of care technology that consolidates the colposcope into a hand-held device and with an integrated visible light diffuse reflectance optical spectroscope that rapidly measures oxygen saturation, neovascularization and the morphological composition of acetowhitened sites identified by VIAM that are known to be altered with neoplastic progressions. The colpospectroscope will enable surveillance with VIAM followed by spectroscopy (in lieu histopathology on a biopsy specimen) such that cervical dysplasia can be diagnosed "on the spot" thereby enabling a see and treat paradigm for women with cervical pre-cancer with cryotherapy and/or LEEP in at the same visit.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nirmala Ramanujam其他文献
Nirmala Ramanujam的其他文献
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{{ truncateString('Nirmala Ramanujam', 18)}}的其他基金
A novel strategy to see and treat breast cancer: translation to intra-operative breast margin assessment
观察和治疗乳腺癌的新策略:转化为术中乳房边缘评估
- 批准号:
9387262 - 财政年份:2017
- 资助金额:
$ 20.22万 - 项目类别:
Culturally appropriate screening and diagnosis of cervical cancer in East Africa
东非文化上适宜的宫颈癌筛查和诊断
- 批准号:
8864360 - 财政年份:2015
- 资助金额:
$ 20.22万 - 项目类别:
Culturally appropriate screening and diagnosis of cervical cancer in East Africa
东非文化上适宜的宫颈癌筛查和诊断
- 批准号:
9109589 - 财政年份:2015
- 资助金额:
$ 20.22万 - 项目类别:
A Viable Solution for a See and Treat Paradigm for Cervical Pre-cancer in Africa
非洲宫颈癌前病变“即见即治”模式的可行解决方案
- 批准号:
8882726 - 财政年份:2015
- 资助金额:
$ 20.22万 - 项目类别:
Culturally appropriate screening and diagnosis of cervical cancer in East Africa
东非文化上适宜的宫颈癌筛查和诊断
- 批准号:
9322308 - 财政年份:2015
- 资助金额:
$ 20.22万 - 项目类别:
A Quantitative Optical Sensor to Monitor Pre-Clinical Tumor Vascular Physiology
用于监测临床前肿瘤血管生理学的定量光学传感器
- 批准号:
8652715 - 财政年份:2013
- 资助金额:
$ 20.22万 - 项目类别:
A Quantitative Optical Sensor to Monitor Pre-Clinical Tumor Vascular Physiology
用于监测临床前肿瘤血管生理学的定量光学传感器
- 批准号:
8313363 - 财政年份:2012
- 资助金额:
$ 20.22万 - 项目类别:
A Novel Optical Spectral Imaging System for Rapid Imaging of Breast Tumor Margins
一种用于乳腺肿瘤边缘快速成像的新型光谱成像系统
- 批准号:
8645626 - 财政年份:2011
- 资助金额:
$ 20.22万 - 项目类别:
Smart Optical Sensor for Detection of Cervical Cancer In the Developing World
用于发展中国家宫颈癌检测的智能光学传感器
- 批准号:
8204324 - 财政年份:2011
- 资助金额:
$ 20.22万 - 项目类别:
A Novel Optical Spectral Imaging System for Rapid Imaging of Breast Tumor Margins
一种用于乳腺肿瘤边缘快速成像的新型光谱成像系统
- 批准号:
8443832 - 财政年份:2011
- 资助金额:
$ 20.22万 - 项目类别:
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