Detroit Research on Cancer Survivors (Detroit ROCS)

底特律癌症幸存者研究（底特律 ROCS）

• 批准号: 9107577
• 负责人: TERRANCE L ALBRECHT
• 金额: $ 166.67万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-27 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9107577
• 关键词: Address; Adherence; Adult; Affect; African American; Aftercare; Alcohol consumption; Annual Reports; Area; Behavioral; Breast; Cancer Burden; Cancer Prognosis; Cancer Survivor; Cancer Survivorship; Caregivers; Caring; Cessation of life; Characteristics; Collection; Colon; Colon Carcinoma; Communities; Community Networks; Comorbidity; Comprehensive Cancer Center; County; Data; Death Records; Depressed mood; Diagnosis; Diet; Disease; Early Diagnosis; Early treatment; Economic Burden; Emotional; Enrollment; Evaluation; Fibrinogen; Frequencies; Funding; Genetic; Grant; Healthcare Systems; Home environment; Incidence; Individual; Length; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical; Medical Record Linkage; Medical Records; Michigan; Minority; National Cancer Institute; Newly Diagnosed; Online Systems; Outcome; Participant; Patient Outcomes Assessments; Patients; Pattern; Phonation; Physical activity; Population; Population-Based Registry; Poverty; Prostate; Provider; Quality of life; Recurrence; Registries; Reporting; Research; Retrieval; SEER Program; Saliva; Severity of illness; Smoking; Social support; Spouse Caregiver; Surveys; System; Telephone; Telephone Interviews; Testing; Treatment outcome; United States; Work; anticancer research; cancer diagnosis; cancer health disparity; cancer type; cohort; community based participatory research; cost; design; experience; family support; follow up assessment; follow-up; improved; indexing; individual patient; malignant breast neoplasm; medically underserved; metropolitan; minority communities; mortality; neoplasm registry; population based; programs; public health relevance; response; social; survival outcome; survivorship; tumor; tumor progression

 DESCRIPTION (provided by applicant): Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The determinants of cancer progression, recurrence, mortality and quality of life in African American cancer survivors are not well studied, with biologic, genetic, environmental, social and behavioral factors contributing. The ~25,000 cancers reported annually among residents of metropolitan Detroit provide the basis for a unique cohort of African American cancer survivors that will include cancer types with both poor outcomes overall (lung cancer and colon cancer) and better outcomes overall (breast and prostate cancer) to study both short term and longer term determinants of survival. The cohort will also include caregivers of a subset of the cases to develop research in the areas of family support and economic burden. The specific aims are to: 1) Enroll a total of 5,560 lung, prostate, breast, and colon population-based African American cancer cases into the Detroit Research on Cancer Survivors (Detroit ROCS) cohort. Participation at baseline will include a web-based or telephone interview, saliva collection, and tumor block retrieval. 2) Enroll a total of 2,780 caregivers of these cases. For 50% of the cancer cases, one spouse/caregiver will be asked to participate in a web-based or telephone interview. 3) Conduct yearly follow-up for all cancer cases and their caregivers. 4) Evaluate the need for more frequent follow-up and assessment by collecting patient reported outcome data early in the disease course. This will enable more accurate identification of determinants of outcomes. Most cohorts are followed annually or less often. For this cancer cohort, more frequent follow-up will be tested in a subset of the population to evaluate the most valid and least burdensome strategies for participants to report quality of life data during the fist year post treatment. The resulting population-based, African American cancer cohort will support studies addressing determinants of cancer prognosis and progression, survival, and outcomes of cancer-directed therapies. It will be one of the few cohorts to include a large minority community already actively engaged in cancer research, providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population. This work will be conducted in the context of a community uniquely engaged through our: 1) Community Network Program Center grant (U54) supporting a community based participatory research (CBPR) approach to addressing cancer disparities; 2) NCI-funded SEER cancer registry for population-based ascertainment of cancer cases in an economically depressed area with a large minority population; and 3) an NCI-designated Comprehensive Cancer Center with a strong transdisciplinary research program in cancer health disparities.

 描述（由申请人提供）：尽管在早期检测和治疗方面取得了进展，但非裔美国人的癌症发病率仍然不成比例地高，首先被诊断出的疾病处于更晚期，并且死亡率比其他人群更高。非裔美国癌症幸存者的癌症进展、复发、死亡率和生活质量的决定因素尚未得到充分研究，生物、遗传、环境、社会和行为因素都有影响。底特律大都市居民每年报告的约 25,000 种癌症为非裔美国癌症幸存者的独特队列提供了基础，该队列将包括总体结果较差（肺癌和结肠癌）和总体结果较好（乳腺癌和前列腺癌）的癌症类型，以研究短期和长期生存决定因素。该队列还将包括一部分病例的护理人员，以开展家庭支持和经济负担领域的研究。具体目标是： 1) 将总共 5,560 名非裔美国人肺癌、前列腺癌、乳腺癌和结肠癌病例纳入底特律癌症幸存者研究 (Detroit ROCS) 队列。基线参与将包括基于网络或电话访谈、唾液收集和肿瘤块检索。 2) 总共登记了 2,780 名此类病例的护理人员。 对于 50% 的癌症病例，一名配偶/照顾者将被要求参加网络或电话访谈。 3) 对所有癌症病例及其护理人员进行年度随访。 4) 通过在病程早期收集患者报告的结果数据来评估是否需要更频繁的随访和评估。这将能够更准确地识别结果的决定因素。大多数队列每年或较少频率进行随访。对于这个癌症队列，将在一部分人群中进行更频繁的随访，以评估参与者在治疗后第一年报告生活质量数据的最有效和最不负担的策略。由此产生的基于人群的非裔美国人癌症队列将支持研究癌症预后和进展、生存以及癌症定向治疗结果的决定因素。它将是少数几个已经积极参与癌症研究的少数群体之一，提供大量数据和生物样本，以促进旨在理解和解决该人群不良结果决定因素的研究。这项工作将在社区的背景下进行，通过我们的独特参与：1）社区网络计划中心拨款（U54）支持基于社区的参与性研究（CBPR）方法来解决癌症差异； 2) NCI 资助的 SEER 癌症登记处，用于在少数民族人口较多的经济萧条地区进行基于人群的癌症病例查明； 3) NCI 指定的综合癌症中心，在癌症健康差异方面拥有强大的跨学科研究项目。