Maintenance and Extension of a Cohort of Career Firefighters as a Non-WTC Exposed Comparison for the FDNY Firefighter Cohort

项目摘要 数百项对接触WTC的救援/恢复人员和其他人的研究报告了发病率和 疾病的流行，通常被认为是由于暴露于 世贸中心灾难现场。然而，由于尚未确定合适的比较组， 最关键的问题仍然没有得到回答：明显的疾病和症状在多大程度上 与WTC暴露相关的过度行为？ 该项目旨在解决詹姆斯·L·扎德罗加9/11健康和补偿法案的研究 任务是回答与世贸中心有关的身心健康状况的关键问题 通过加强我们对世贸中心暴露火灾的开创性研究来实施恐怖袭击 纽约市消防局(FDNY)通过不断增加一名消防员 建立了对WTC袭击没有做出反应的消防员的比较队列。消防员 比较队列由来自旧金山、芝加哥和费城的职业消防员组成 他们很可能经历过类似的与工作相关的暴露。继续对这两人进行跟踪调查 队列(以下称为“FDNY FF队列”和“FF比较队列”)提供了这种可能性 为工作场所内外的工人确定预防战略。此外，我们认为 维护FF比较队列提供了一个独特的机会来建立出色的比较 在第一反应人员中进行一系列与灾难有关的研究的小组，这是国家 职业安全与健康研究所(NIOSH)的领导，是目前提出的目标 寻求解决的问题。这项为期5年的建议的具体目标如下： 目标1：确定FDNY FF队列中的消防员是否患较高癌症 与消防比较队列中的消防员相比，发病率更高。 目标2：从消防对比中建立一个特征良好的消防员队列 终身跟踪的队列。 目标3：比较9/11事件后的患病率和身心健康发生率 FDNY FF队列和FF比较队列中的症状和诊断条件。

Project Abstract Hundreds of studies of WTC-exposed rescue/recovery workers and others reported the incidence and prevalence of conditions that are thought to occur more commonly as a consequence of exposure to the WTC disaster site. And yet, because a suitable comparison group has not yet been identified, the most critical question remains unanswered: to what extent are apparent disease and symptom excesses associated with WTC-exposures? This project seeks to address the James L. Zadroga 9/11 Health & Compensation Act research mandate to answer critical questions about physical and mental health conditions related to the WTC terrorist attacks by enhancing our previous ground-breaking research on the WTC-exposed Fire Department of the City of New York (FDNY) firefighter cohort through the ongoing inclusion of an established comparison cohort of firefighters who did not respond to the WTC attacks. The Firefighter Comparison Cohort is comprised of career firefighters from San Francisco, Chicago, and Philadelphia who are likely to have experienced similar job-related exposures. Continued follow-up of these two cohorts (hereafter called “the FDNY FF Cohort” and “the FF Comparison Cohort”) offers the possibility of identifying prevention strategies for workers in the workplace and beyond. Further, we believe that maintaining the FF Comparison Cohort offers a unique opportunity to establish an excellent comparison group for a range of disaster-related research in first responders, which is a stated goal of National Institute of Occupational Safety and Health (NIOSH) leaders, and is the goal that the current proposal seeks to address. The specific objectives of this 5-year proposal are as follows: Aim 1: Determine whether firefighters in the FDNY FF Cohort have higher cancer incidence rates than firefighters in the FF Comparison Cohort. Aim 2: Establish a well-characterized cohort of firefighters from the FF Comparison Cohort for lifelong follow-up. Aim 3: Compare the post-9/11 prevalence and incidence of physical and mental health symptoms and diagnosed conditions in the FDNY FF Cohort and the FF Comparison Cohort.