Liver disease in HIV-HBV co-infection

HIV-HBV 合并感染中的肝病

• 批准号: nhmrc : 1024406
• 负责人: A/Pr Gail Matthews
• 金额: $ 47.57万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/liver-disease-hiv-co-infection/110346
• 关键词: Liver; disease; HIV; HBV; co

Morbidity and mortality secondary to liver disease is greatly increased in people co-infected with HIV and HBV compared to those infected with HBV alone. Mortality remains elevated even after treating both viruses. This project will investigate the mechanism of how HIV accelerates liver disease in patients co-infected with HBV. We hypothesize that this occurs by combined effects of HIV and HBV on inflammation in the liver. These studies could potentially lead to new treatments for liver disease.

与仅感染HBV的人相比，合并感染HIV和HBV的人继发于肝病的发病率和死亡率大大增加。即使在治疗两种病毒后，死亡率仍然升高。该项目将研究HIV如何加速合并感染HBV的患者的肝脏疾病的机制。我们假设这是由于HIV和HBV对肝脏炎症的联合作用而发生的。这些研究可能会导致肝病的新治疗方法。