Longitudinal Assessment of Spinal Cord Structural Plasticity using DTI in SCI Patients

使用 DTI 对 SCI 患者脊髓结构可塑性进行纵向评估

• 批准号: 9221374
• 负责人: Bing Yao
• 金额: $ 18.88万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9221374
• 关键词: Acute; Amyotrophic Lateral Sclerosis; Animal Model; Animals; Axon; Biological Markers; Brain; Brain Injuries; Cervical; Chronic; Classification; Clinical; Clinical assessments; Cognitive; Cutaneous; Data; Detection; Diagnosis; Diffusion Magnetic Resonance Imaging; Evaluation; Evolution; Fiber; Gold; Hour; Human; Image; Imaging Device; Imaging Techniques; Individual; Injury; International; Intervention; Investigation; Knowledge; Learning; Longitudinal Studies; Lower Extremity; Magnetic Resonance Imaging; Measurement; Measures; Methods; Microscopic; Monitor; Motor; Motor Neurons; Movement; Muscle; Nerve Fibers; Nervous System Trauma; Neurologic; Neurons; Outcome Measure; Pathologic; Pathway interactions; Patient Self-Report; Patients; Performance; Physicians; Plasticizers; Process; Protocols documentation; Recovery; Rehabilitation therapy; Scanning; Sensorimotor functions; Sensory; Spinal Cord; Spinal Cord Plasticity; Spinal cord injury; Spinal cord injury patients; System; Testing; Time; Treatment Factor; Upper Extremity; Visit; Wound Repair Pathway; accurate diagnosis; base; clinical Diagnosis; design; effective therapy; follow-up; functional outcomes; human imaging; human study; improved; indexing; injured; injury and repair; insight; neuroimaging; neurophysiology; novel; outcome forecast; pediatric patients; prognostic value; programs; public health relevance; repaired; research clinical testing; restoration; spinal cord imaging; standard measure; targeted treatment; tool; treatment planning; water diffusion; white matter

 DESCRIPTION (provided by applicant): Current clinical and outcome measures in rehabilitation of spinal cord injury (SCI) rely on self- reports to monitor and evaluate the functional outcome in patients with SCI and clinical neuroimaging is not sensitive to detect SCI and SCI progression or repair. Moreover, it is difficult to assess and evaluate the SC function below the neurological injury level. The current project explores the potential utility of diffusio tensor imaging (DTI) of SC to monitor SCI repair as a result of rehabilitative treatment and spontaneous recovery, and relates quantitative DTI parameter changes to motor performance gains. By scanning the SC longitudinally, structural microscopic adaptations are expected to be quantified by DTI following the injury and rehabilitation. Motor function and other clinical variables will be examined at baseline and each follow-up visit and we will examine the linkage between the DTI parameters and clinical measurements and thus gain more insights in the underlying mechanism of how the wounded pathways are repaired to reinstate sensorimotor function. This knowledge may help clinicians design more effective rehabilitative treatment plans for patients with SCI. The proposed neuroimaging measurement may potentially serve as a biomarker of SCI, its recovery and motor and sensory function restoration.

 描述（由申请人提供）：目前脊髓损伤（SCI）康复的临床和结果测量依赖于自我报告来监测和评估 SCI 患者的功能结果，而临床神经影像对于检测 SCI 和 SCI 进展或修复并不敏感。而且，神经损伤水平以下的SC功能很难评估和评价。当前的项目探索 SC 弥散张量成像 (DTI) 在监测康复治疗和自发恢复导致的 SCI 修复方面的潜在效用，并将定量 DTI 参数变化与运动性能增益联系起来。通过纵向扫描 SC，预计在受伤和康复后通过 DTI 量化结构微观适应。我们将在基线和每次随访时检查运动功能和其他临床变量，我们将检查 DTI 参数和临床测量之间的联系，从而更深入地了解如何修复受伤通路以恢复感觉运动功能的潜在机制。这些知识可以帮助临床医生为 SCI 患者设计更有效的康复治疗计划。所提出的神经影像测量有可能作为 SCI、其恢复以及运动和感觉功能恢复的生物标志物。