Histology

____________________________________________________________________________________ 项目摘要 摘要：北达科他州大学医学院组织学核心设施的目标 医学和健康科学，是提供高质量的仪器，样品制备和培训 在广泛的基础和高级组织学技术中进行Cobre研究 调查人员。组织学核心设施将设在新的UND SMHS大楼的一层 毗邻已建立的成像核心，该核心包括多光子、共焦、生命内成像、 荧光、TIRF和电子显微镜套件。组织学设施将对完成 五名初级调查人员提出的科学项目。此外，组织学核心将 允许初级调查人员获得设备和技术专长，以准备广泛的 各种高分辨率成像技术。核心总监和技术人员将提供所有项目 研究人员和他们的学生/工作人员在实验设计、样品准备方面提供帮助 形态分析的类型，以及选择适当的成像分辨率水平。 此外，该核心将为调查人员及其受训人员提供广泛的全面培训 各种样品制备技术和跨组织特定应用范围的分析。 为了最大限度地发挥NIH对北达科他州生物医学研究的投资的影响，组织学 核心基金将为联合国开发计划署内部的其他调查人员提供接触和支持 不属于医学院的研究人员，以及来自北达科他州其他大学的研究人员 例如北达科他州立大学、通过INBRE的部落学院和其他研究机构 作为美国农业部-大福克斯人类营养研究中心；然而，按服务收费的方法将是 适用于科布雷以外的调查人员，这些费用将有助于维持这个中心。

____________________________________________________________________________________ Project Summary Summary: The objective of the Histology Core Facility at the University of North Dakota School of Medicine and Health Sciences, is to provide high quality instrumentation, sample preparation and training in a wide spectrum of fundamental and advanced histological techniques to COBRE research investigators. The Histology Core Facility will be located in the first level of the new UND SMHS Building adjacent to the established Imaging Core which consists of the multiphoton, confocal, intravital imaging, fluorescent, TIRF and electron microscopy suites. The Histology facility will be critical to the completion of the proposed scientific projects from the five junior investigators. Furthermore, the Histology core will allow junior investigators to access the equipment and technical expertise to prepare samples for a wide variety of high resolution imaging techniques. The Core Director and technical staff will provide all project investigators and their students/staff assistance in experimental design, sample preparations for specific types of morphological analyses, and selection of the appropriate levels of imaging resolution. Additionally, the core will provide investigators and their trainees with comprehensive training in a wide variety of sample preparation techniques and analysis across a spectrum of tissue-specific applications. To maximize the impact of the NIH investment in biomedical research within North Dakota, the Histology Core Facility will provide access and support to other investigators, within the UND SMHS UND researchers who are not part of the medical school, and researchers from other North Dakota universities such as North Dakota State University, tribal colleges through INBRE, and other research institutions such as USDA-Grand Forks Human Nutrition Research Center; however, a fee-for-service approach will be applied to investigators outside this COBRE, and these fees will help to sustain this center.