IGF::OT::IGF Constructed Environments for Successfully Sustaining Abstinence Through Immersive and On-Demand Treatment. Period of Performance: September 22, 2017 - March 21, 2018. N43DA-17-5583.

Charles River Analytics和我们在马萨诸塞州总医院和虚拟现实医疗中心的合作伙伴建议设计和演示通过沉浸式和按需治疗（CESSATION）成功维持禁欲的构建环境。我们将使用我们的内部游戏引擎和内容（线索）构建VR环境，这些游戏引擎和内容（线索）是多样化的，现实的，位置合理的，支持传统的心理治疗提供，并使用基于研究的叙事和游戏设计原则来制作沉浸式和引人入胜的内容，以激励持续使用。我们将使用概率模型（例如，贝叶斯网络）和机器学习（例如，神经网络）来从患者数据和临床医生输入中学习，以帮助以适合于个体患者的方式选择和组合治疗。最后，CESSATION将以可理解的方式向临床医生传达信息，并为他们提供足够的元信息，以促进对系统的适当信任。拟议的第一阶段工作的预期结果是：（1）初始领域分析;（2）初始VR内容;（3）初始激励内容;（4）原型传感器功能;（5）原型干预定制组件;（6）原型临床医生用户界面和远程患者数据服务器;以及（7）初始第一阶段停止原型演示和评估。

Charles River Analytics and our partners at Massachusetts General Hospital and Virtual Reality Medical Center propose to design and demonstrate Constructed Environments for Successfully Sustaining Abstinence Through Immersive and On-Demand Treatment (CESSATION). We will build VR environments using our in-house game engine and content (cues) that are diverse, realistic, and well-placed, bolstering traditional psychological therapy delivery, and use research-based principles of narrative and game design to produce immersive and engaging content to motivate continued use. We will use probabilistic models (e.g., Bayesian networks) and machine-learning (e.g., neural nets) to learn from patient data and clinician input to assist in selecting and combining therapies in a way that is tailored to the individual patient. Finally, CESSATION will communicate information to clinicians in a manner that is understandable, and gives them enough meta-information to foster appropriate trust in the system. The anticipated results of the proposed Phase I work are: (1) an initial domain analysis; (2) initial VR content; (3) initial motivational content; (4) prototype sensor capabilities; (5) a prototype Intervention Tailoring Component; (6) a prototype Clinician User Interface and Remote Patient Data Server; and (7) an initial Phase I CESSATION prototype demonstration and evaluation.