Health Services Career Development: Improving Medical Decisions in Ovarian Cancer

卫生服务职业发展：改善卵巢癌的医疗决策

• 批准号: 9276650
• 负责人: Larissa Alejandra Meyer
• 金额: $ 17.05万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9276650
• 关键词: Adjuvant Chemotherapy; Applications Grants; Award; Cancer Patient; Cantor; Clinical; Colostomy Procedure; Competence; Complex; Conflict (Psychology); Consensus; Critiques; Data; Data Analyses; Data Set; Databases; Decision Aid; Decision Analysis; Decision Making; Development; Disease; Environment; Epithelial ovarian cancer; Europe; Excision; Goals; Gynecologic Oncologist; Health; Health Services; Health Services Research; Ileostomy; Individual; International; Intervention; Interview; K-Series Research Career Programs; Life; Malignant Female Reproductive System Neoplasm; Malignant neoplasm of ovary; Medical; Medicare; Mentors; Methodology; Methods; Modality; Modeling; Morbidity - disease rate; Neoadjuvant Therapy; Newly Diagnosed; Online Systems; Operative Surgical Procedures; Outcome; Patient Preferences; Patient-Centered Care; Patient-Focused Outcomes; Patients; Performance; Physicians; Platinum; Process; Provider; Publishing; Qualitative Research; Quality of Care; Randomized; Randomized Controlled Trials; Recommendation; Research; Research Methodology; Research Personnel; Research Training; Residual Tumors; Science; Site; Source; Structure; Symptoms; Techniques; Testing; Time; Toxic effect; Training; Tumor Debulking; United States; University of Texas M D Anderson Cancer Center; Woman; Women Physicians; administrative database; base; career; career development; chemotherapy; clinical predictors; clinically relevant; design; evidence base; experience; improved; novel; oncology; patient oriented; predict clinical outcome; preference; prospective; prototype; public health relevance; randomized trial; skills; support tools; survival outcome; taxane; tool; tool development; tumor; user centered design

 DESCRIPTION (provided by applicant): This is an application for a K07 award for Dr. Larissa Meyer, a gynecologic oncologist at The University of Texas MD Anderson Cancer Center. Dr. Meyer is establishing herself as a young investigator in health services research of gynecologic malignancies. This K07 award will provide Dr. Meyer with the necessary protected research time and support to accomplish the following goals: 1) to gain experience with advanced analytic and statistical techniques utilizing large national databases; 2) to build decision analytc models; 3) to design and analyze studies with qualitative research methods; 4) to obtain practical hands on experience building tools for shared medical decision making; 5) to develop an independent research career in health services research. To achieve these goals, Dr. Meyer has assembled a mentoring team comprised of a primary mentor, Dr. Sharon Giordano, Chair of Health Services Research, who conducts analyses of large administrative databases, and two co-mentors: Dr. Scott Cantor, a clinical decision analyst who focuses on decision analyses in oncology; and Dr. Robert Volk, whose expertise in decision-making spans research on patients' preferences and values to applied studies in patient decision support and decision aids for promoting informed choice. Although it is well accepted that optimal therapy for advanced ovarian cancer remains a combination of tumor debulking surgery and platinum/taxane based chemotherapy, there is still an ongoing heated international debate focused on whether it is better to start with primary debulking surgery (PDS) or neoadjuvant chemotherapy (NAC). Dr. Meyer's research will focus on 1) building a decision analytic model that incorporates the best published evidence supplemented by primary analyses of outcomes with PDS or NAC in national databases and the high quality MD Anderson ovarian cancer database (Aim 1), and patient preferences and experiences (assessment of symptom burden) when starting treatment with primary debulking surgery or neoadjuvant chemotherapy (Aim 2). Aim 3 will entail the design and iterative testing of a shared medical decision tool prototype that combines predictive clinical factors with interactive values clarification methodology to support patients and physicians in the complex process of deciding on primary treatment for advanced ovarian cancer. This focused research and training plan will provide Dr. Meyer with the skills needed to impact women with gynecologic malignancies through meaningful, patient centered, health services research, and will form the basis for a prototype decision tool to test in a prospective, multi-site, randomized controlled trial for women with advanced ovarian cancer. This study will be proposed in an R01 grant application that will be submitted before the end of the career development award period.