HIV and Aging: From the Mitochondria to the Metropolis

艾滋病毒与衰老：从线粒体到大都市

• 批准号: 9327838
• 负责人: MARCIA McDonnell Holstad
• 金额: $ 3.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9327838
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Aging; Alzheimer' s Disease; Area; Basic Science; Behavioral; Behavioral Genetics; Biological; Biological Markers; Caregivers; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Development; Disease; Educational workshop; Elderly; Environmental Health; Evaluation; Fostering; Foundations; Funding Opportunities; Future; Geography; HIV; Health; Health Services; Health behavior; Hepatitis C; Homelessness; Individual; International; Intervention; Knowledge; Lead; Mentors; Mitochondria; NIH Office of AIDS Research; Neurocognitive; Outcome; Paper; Persons; Physical environment; Physiological; Population; Publications; Publishing; Recommendation; Research; Research Infrastructure; Research Personnel; Research Proposals; Science; Scientist; Shapes; Speed; Stress; Structure; Translating; Translational Research; Translations; United States Health Resources and Services Administration; United States National Institutes of Health; Universities; Veterans; Virus; Woman; age related; biobehavior; clinical care; ethnic minority population; experience; follow-up; frailty; functional decline; informal care; interdisciplinary collaboration; interest; marginally housed; men who have sex with men; multidisciplinary; multiple chronic conditions; named group; patient oriented research; person centered; programs; psychosocial; racial and ethnic; research and development; response; social; special interest group; success; symposium; transgender; web site; working group

HIV and Aging: From the Mitochondria to the Metropolis ABSTRACT Building on the success of our first NIA-supported HIV and Aging conference held in October 2014, the primary aims of this R13 application are to: a) Advance the state of the science on HIV and aging and speed translation of findings to the community by conducting 3 conferences over a 5 year period; and b) Create and build a pipeline of diverse multidisciplinary scientists who will conduct translational research focusing on the gaps in knowledge and research related to HIV and Aging. The findings and recommendations from the Office of AIDS Research Working Group on HIV and Aging (OAR WG) form the foundation and framework for our conferences. Our intent is to attract and bring together experts, clinicians, early stage investigators, and community leaders from the fields of both HIV and Aging. We expect these conferences to lead to the following outcomes: a) increase knowledge in the field and provide a viable mechanism for translating basic and clinical science findings to the community of persons living with HIV/AIDS (PLWH) (i. e, from the “mitochondria to the metropolis”); b) Interdisciplinary collaborations focused on clinical and research gaps; c) Development of a pipeline of new HIV and Aging researchers and development of research proposals related to the research agenda outlined by the OAR WG and operationalized via the conferences; d) dissemination of conference content to a broad range of professionals. The conferences will be planned by Executive and Scientific Boards with substantial representation from the community and include content experts for planning the second and third conferences. The Executive Board will be led by Co-PI’s who co-direct Emory’s CFAR Scientific Working Group on HIV and Aging with strong collaboration by CFARs and Centers for Aging. All conferences will be held in Atlanta, GA. The specific themes of the three conferences include: Functional Wellness (2017): A person-centered, bio-behavioral approach to maximizing health and wellness that acknowledges and addresses both internal (e.g., health behavior, individual responses to stress and illness) and external (e.g., environmental health) factors that impact aging. Aging and Special Populations (2019): The unique needs of sub-groups of aging PLWH who require specialized interventions and treatment. They include racial/ethnic minorities; women; MSM; transgender; veterans; substance users; those co-infected with hepatitis C; and homeless or marginally housed. Population Determinants of Health (2021): The range of individual behavioral, genetic and biological, and social determinants, including social/societal characteristics, physical environment, and health services, that shape health and wellness of older PLWH. All three conferences and their corresponding themes address critical knowledge gaps identified by the OAR WG. Each conference will weave together basic and physiologic science, behavioral/psychosocial science, clinical aspects of care, and the community experiences and perspectives of PLWH and their caregivers.

HIV与衰老：从线粒体到大都会 摘要 在我们于2014年10月举行的第一次由NIA支持的艾滋病毒和老龄化会议取得成功的基础上， 这项R13应用的目的是：a）推进艾滋病毒和衰老的科学状态，并加速转化 通过在5年内举办3次会议，向社区提供调查结果;以及B）创建和建立一个 不同的多学科科学家谁将进行转化研究，重点放在差距管道 与艾滋病毒和老龄化有关的知识和研究。艾滋病办公室的调查结果和建议 艾滋病毒和老龄化研究工作组（OAR WG）是我们的基础和框架， 两会我们的目的是吸引和汇集专家，临床医生，早期研究人员， 来自艾滋病毒和老龄化领域的社区领导人。我们期望这些会议能产生以下结果 成果：a）增加该领域的知识，并提供一个可行的机制， 向艾滋病毒/艾滋病感染者社区提供科学研究结果（i.即从“线粒体到 大都会”）; B）关注临床和研究差距的跨学科合作; c）开发 新的艾滋病毒和老龄化研究人员的管道和与研究有关的研究提案的发展 由OAR工作组概述并通过会议实施的议程; d）传播会议 内容广泛的专业人士。会议将由执行委员会和科学委员会规划 有来自社区的大量代表，包括内容专家， 第三次会议。执行委员会将由共同PI领导，共同指导埃默里大学的CFAR科学工作 艾滋病毒和老龄问题小组与老龄问题中心和老龄问题中心密切合作。所有会议将在 在亚特兰大，GA。三个会议的具体主题包括：功能健康（2017）：A 以人为本，生物行为的方法，以最大限度地提高健康和健康，承认和 解决了内部（例如，健康行为，个体对压力和疾病的反应）和外部（例如， 环境健康）影响衰老的因素。老龄化和特殊人群（2019）：独特的需求 需要专门干预和治疗的老年艾滋病毒携带者亚组。包括种族/民族 少数民族;妇女;男男性接触者;变性人;退伍军人;物质使用者;合并感染丙型肝炎的人;以及 无家可归或住在边缘地带。健康的人口决定因素（2021）：个人行为， 遗传和生物以及社会决定因素，包括社会/社会特征、物理环境， 和卫生服务，塑造老年艾滋病毒携带者的健康和福祉。所有三个会议及其 相应的主题解决了OAR WG确定的关键知识差距。每次会议都将编织 基础和生理科学、行为/心理社会科学、护理的临床方面，以及 艾滋病毒/艾滋病感染者及其照顾者的社区经验和观点。